Implicating candidate genes at GWAS signals by leveraging topologically associating domains
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Human Genetics"
DOI: 10.1038/ejhg.2017.108
Abstract: Genome-wide association studies (GWAS) have contributed significantly to the understanding of complex disease genetics. However, GWAS only report association signals and do not necessarily identify culprit genes. As most signals occur in non-coding regions of… read more here.
Keywords: associating domains; gwas signals; association; candidate genes ... See more keywords
GWAS signals revisited using human knockouts
Sign Up to like & getrecommendations! Published in 2018 at "Genetics in Medicine"
DOI: 10.1038/gim.2017.78
Abstract: PurposeGenome-wide association studies (GWAS) have been instrumental to our understanding of the genetic risk determinants of complex traits. A common challenge in GWAS is the interpretation of signals, which are usually attributed to the genes… read more here.
Keywords: gwas signals; interpretation; signals revisited; using human ... See more keywords
Transcriptome Analysis of Bovine Rumen Tissue in Three Developmental Stages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.821406
Abstract: Rumen development is a crucial physiological challenge for ruminants. However, the molecular mechanism regulating rumen development has not been clearly elucidated. In this study, we investigated genes involved in rumen development in 13 rumen tissues… read more here.
Keywords: three developmental; rumen development; developmental stages; gwas signals ... See more keywords