GWAS summary-based pathway analysis correcting for the genetic confounding impact of environmental exposures
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbx025
Abstract: Genome-wide association study (GWAS)-based pathway association analysis is a powerful approach for the genetic studies of human complex diseases. However, the genetic confounding effects of environment exposure-related genes can decrease the accuracy of GWAS-based pathway… read more here.
Keywords: analysis; environmental exposures; genetic confounding; gwas summary ... See more keywords
simGWAS: a fast method for simulation of large scale case–control GWAS summary statistics
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty898
Abstract: Abstract Motivation Methods for analysis of GWAS summary statistics have encouraged data sharing and democratized the analysis of different diseases. Ideal validation for such methods is application to simulated data, where some ‘truth’ is known.… read more here.
Keywords: control; gwas; simulation; gwas summary ... See more keywords
Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1101/2022.03.02.482630
Abstract: To infer a causal relationship between two traits, several correlation-based causal direction (CD) methods have been proposed with the use of SNPs as instrumental variables (IVs) based on GWAS summary data for the two traits;… read more here.
Keywords: presence; directional causal; gwas summary; correlated pleiotropy ... See more keywords
Gene Set Enrichment Analysis Detected Immune Cell-Related Pathways Associated with Primary Sclerosing Cholangitis
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2371347
Abstract: Aim To explore various immune cell-related causal pathways for primary sclerosing cholangitis (PSC). Methods Immune cell-related pathway association study was conducted via integrative analysis of PSC GWAS summary and five immune cell-related eQTL datasets. The… read more here.
Keywords: cell; cell related; immune cell; psc ... See more keywords
Combining Mendelian randomization and network deconvolution for inference of causal networks with GWAS summary data
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010762
Abstract: Mendelian randomization (MR) has been increasingly applied for causal inference with observational data by using genetic variants as instrumental variables (IVs). However, the current practice of MR has been largely restricted to investigating the total… read more here.
Keywords: network; mendelian randomization; gwas summary; causal ... See more keywords