Evaluation of Resistance Development to the Gwt1 Inhibitor Manogepix (APX001A) in Candida Species
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DOI: 10.1128/aac.01387-19
Abstract: Manogepix (MGX) targets the conserved fungal Gwt1 enzyme required for acylation of inositol early in the glycosylphosphatidylinositol biosynthesis pathway. The prodrug fosmanogepix is currently in clinical development for the treatment of invasive fungal infections. ABSTRACT… read more here.
Keywords: reduced susceptibility; gwt1; development; resistance ... See more keywords