Mitigating type 1 error inflation and power loss in GxE PRS: Genotype–environment interaction in polygenic risk score models
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DOI: 10.1002/gepi.22546
Abstract: The use of polygenic risk score (PRS) models has transformed the field of genetics by enabling the prediction of complex traits and diseases based on an individual's genetic profile. However, the impact of genotype–environment interaction… read more here.
Keywords: risk; gxe; prs; type error ... See more keywords
A Multi‐Phenotype Approach to Joint Testing of Main Genetic and Gene‐Environment Interaction Effects
Sign Up to like & getrecommendations! Published in 2025 at "Statistics in Medicine"
DOI: 10.1002/sim.70253
Abstract: Gene‐environment (GxE) interactions crucially contribute to complex phenotypes. The statistical power of a GxE interaction study is limited mainly due to weak GxE interaction effect sizes. Joint tests of the main genetic and GxE effects… read more here.
Keywords: gxe effects; gxe; approach; power ... See more keywords