Identification of a Long Lasting Stress Signatures Associated with Enhanced Vulnerability for Depression by Using ‘Omics and Cross Species Approaches
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.144
Abstract: Depression results from the interplay of vulnerability genes with environmental factors, a phenomenon named as ‘gene-environment (GxE) interaction’. To date, GxE interaction studies have been limited to hypothesis-based candidate genes, since genome-wide (GWAS)-based GxE interaction… read more here.
Keywords: depression; cross species; study; gxe interaction ... See more keywords
Gene–environment interactions between HPA-axis genes and childhood maltreatment in depression: a systematic review
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropsychiatrica"
DOI: 10.1017/neu.2020.1
Abstract: Abstract Objective: Gene–environment (GxE) interactions may comprise an important part of the aetiology of depression, and childhood maltreatment (CM), a significant stressor, has consistently been linked to depression. Hence, in this systematic review, we aimed… read more here.
Keywords: depression; gxe interactions; axis genes; hpa axis ... See more keywords
Allele-specific expression reveals interactions between genetic variation and environment
Sign Up to like & getrecommendations! Published in 2017 at "Nature methods"
DOI: 10.1038/nmeth.4298
Abstract: Identifying interactions between genetics and the environment (GxE) remains challenging. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on associations between environmental variables and allele-specific expression. Combining whole-blood RNA-seq with… read more here.
Keywords: specific expression; expression reveals; allele specific; environment ... See more keywords