Immuno-oncology for Gynecologic Malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-41008-7_7
Abstract: Patients with advanced and/or recurrent gynecologic cancers derive limited benefit from currently available cytotoxic and targeted therapies. Successes of immunotherapy in other difficult-to-treat malignancies such as metastatic melanoma and advanced lung cancer have led to… read more here.
Keywords: gynecologic cancers; immuno oncology; oncology gynecologic; cancer ... See more keywords
A high Glasgow prognostic score (GPS) or modified Glasgow prognostic score (mGPS) predicts poor prognosis in gynecologic cancers: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-020-05581-8
Abstract: Purpose The Glasgow Prognostic Score or modified Glasgow Prognostic Score (GPS/mGPS), a novel inflammatory indicator, which acts as a prognostic predictor in various cancers. However, these results are still controversial. In this meta-analysis, we aimed… read more here.
Keywords: mgps; glasgow prognostic; gynecologic cancers; prognostic score ... See more keywords
Immunotherapy: Checkpoint Inhibitors in Lynch-Associated Gynecologic Cancers
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DOI: 10.1007/s11864-019-0676-8
Abstract: Research into novel therapies for gynecologic cancers is underfunded, and as a result, we are still playing catchup with other solid tumors in the realm of immune checkpoint inhibition. This is despite the fact that… read more here.
Keywords: gynecologic cancers; checkpoint inhibitors; immunotherapy checkpoint; checkpoint ... See more keywords
Ethnic Disparities for Gynecologic Cancers in Israel
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Racial and Ethnic Health Disparities"
DOI: 10.1007/s40615-019-00670-0
Abstract: Background Israel’s unique population is comprised of two main ethnic groups—Jews ( 75 %) and Arabs ( 21 %), with differing socioeconomic, cultural, and genetic profiles. This study’s objective was to evaluate disparities in the… read more here.
Keywords: gynecologic cancers; israeli women; ethnic groups; cancer ... See more keywords
Long Non-coding RNA NEAT1 as an Emerging Biomarker in Breast and Gynecologic Cancers: a Systematic Overview
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DOI: 10.1007/s43032-021-00481-x
Abstract: Long non-coding RNAs (lncRNAs) are emerging regulators of cellular pathways, especially in cancer development. Among the lncRNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) forms a scaffold for a nuclear body; the paraspeckle and aberrant expression… read more here.
Keywords: breast gynecologic; non coding; gynecologic cancers; long non ... See more keywords
Clinical characteristics of CNS metastases from primary gynecologic cancers☆
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2019.100518
Abstract: Highlights • Most common symptoms for patients with CNS metastases are headaches and ataxia.• Multiple foci are more common than solitary lesions on initial brain imaging.• The frontal lobe is most likely to be involved.•… read more here.
Keywords: characteristics cns; gynecologic cancers; primary gynecologic; cns metastases ... See more keywords
Investigation of Discrepant MMR IHC and MSI PCR Test Results for Gynecologic Cancers using Next Generation Sequencing.
Sign Up to like & getrecommendations! Published in 2021 at "Human pathology"
DOI: 10.1016/j.humpath.2021.10.004
Abstract: Gynecologic cancers are routinely screened for DNA mismatch repair (MMR) gene mutations using immunohistochemistry (IHC) and/or PCR for MSI (microsatellite instability) to enable selection of immune checkpoint inhibitor therapy and screen for Lynch syndrome. The… read more here.
Keywords: gynecologic cancers; ihc msi; msi; next generation ... See more keywords
Multi-disciplinary summit on genetics services for women with gynecologic cancers: A Society of Gynecologic Oncology White Paper.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.06.002
Abstract: OBJECTIVE To assess current practice, advise minimum standards, and identify educational gaps relevant to genetic screening, counseling, and testing of women affected by gynecologic cancers. METHODS The Society of Gynecologic Oncology (SGO) organized a multidisciplinary… read more here.
Keywords: society gynecologic; genetic testing; gynecologic cancers; genetics ... See more keywords
The roles of pathology in targeted therapy of women with gynecologic cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.11.020
Abstract: The role of the pathologist in the multidisciplinary management of women with gynecologic cancer has evolved substantially over the past decade. Pathologists' evaluation of parameters such as pathologic stage, histologic subtype, grade and microsatellite instability,… read more here.
Keywords: gynecologic cancers; targeted therapy; treatment; women gynecologic ... See more keywords
Management of the toxicities of common targeted therapeutics for gynecologic cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2018.01.010
Abstract: As precision medicine has become a focus in oncology in recent years, many targeted and biologic agents are being used along with or in place of traditional cytotoxic chemotherapy. As these drugs have been developed… read more here.
Keywords: gynecologic cancers; management; common targeted; toxicities common ... See more keywords
Tumor associated macrophages in gynecologic cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2018.01.014
Abstract: The complex tumor microenvironment in gynecologic cancers plays a major role in modulating anti-tumor immune responses. The interaction of cancer cells with the diverse spectrum of immune effector cells has an important impact on the… read more here.
Keywords: gynecologic cancers; tumor associated; associated macrophages; oncology ... See more keywords