Monosaccharide and Disaccharide Saponins of Shade‐Dried Gynostemma Pentaphyllum Confer Metabolic Benefits in Mice With Non‐Alcoholic Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2025 at "Phytotherapy Research"
DOI: 10.1002/ptr.70049
Abstract: Gynostemma pentaphyllum (Thunb.), a traditional medicinal plant, is processed through different methods such as roller drying and shade drying. Shade‐dried G. pentaphyllum (SDGPs) contained monosaccharide and disaccharide saponins, while roller‐dried G. pentaphyllum (RDGPs) contained trisaccharide… read more here.
Keywords: gynostemma pentaphyllum; shade dried; pentaphyllum; disaccharide saponins ... See more keywords
New dammarane-type glycosides from Gynostemma pentaphyllum and their lipid-lowering activity.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104843
Abstract: Gynostemma pentaphyllum (Thunb.) Makino has a long history as food and diary supplement in China. At present, there are some products for hyperlipidemia in the market, including G. pentaphyllum tea, healthy wine and healthy food.… read more here.
Keywords: type glycosides; dammarane type; gynostemma pentaphyllum; pentaphyllum ... See more keywords
Anti-diabetic activity evaluation of a polysaccharide extracted from Gynostemma pentaphyllum.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.12.231
Abstract: In current study, a polysaccharide (GPP) was successfully extracted from Gynostemma pentaphyllum herb. Monosaccharide composition of GPP was rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid in a molar ratio of 4.11:… read more here.
Keywords: gpp; extracted gynostemma; gynostemma pentaphyllum; polysaccharide ... See more keywords
Anti‐atherosclerotic effect of Fermentum Rubrum and Gynostemma pentaphyllum mixture in high‐fat emulsion‐ and vitamin D3‐induced atherosclerotic rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Chinese Medical Association"
DOI: 10.1016/j.jcma.2017.08.018
Abstract: Background: The mixture of Hongqu and gypenosides (HG) is composed of Fermentum Rubrum (Hongqu, in Chinese) and total saponins of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan, in Chinese) in a 3.6:1 weight ratio. Both Hongqu and… read more here.
Keywords: hongqu; fermentum rubrum; atherosclerotic effect; gynostemma pentaphyllum ... See more keywords
Chemical Characterization and Atherosclerosis Alleviation Effects of Gypenosides from Gynostemma pentaphyllum through Ameliorating Endothelial Dysfunction via the PCSK9/LOX-1 Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02681
Abstract: Dietary saponins have the potential to ameliorate atherosclerosis (AS). Gypenosides of Gynostemma pentaphyllum (GPs) have been used as functional foods to exhibit antiatherosclerotic activity. The present study aimed to explore the protective effect, underlying mechanism… read more here.
Keywords: gypenosides gynostemma; pcsk9; pcsk9 lox; gynostemma pentaphyllum ... See more keywords
Dammarane-Type Saponins from Gynostemma pentaphyllum prevent hypoxia-induced neural injury through activation of ERK, Akt and CREB pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06659
Abstract: Gynostemma pentaphyllum possesses the neuroprotective bioactivity. However, the effect of gypenosides on the hypoxia-induced neural damage remains obscure. In this study, Gyp, the active fraction extracted from G. pentaphyllum, and its bioactive compounds as well… read more here.
Keywords: akt creb; erk akt; gynostemma pentaphyllum; injury ... See more keywords
New natural protein tyrosine phosphatase 1B inhibitors from Gynostemma pentaphyllum
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2024.2360063
Abstract: Abstract Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease mainly caused by insulin resistance, which can lead to a series of complications such as cardiovascular disease, retinopathy, and its typical clinical symptom is… read more here.
Keywords: tyrosine phosphatase; gynostemma pentaphyllum; natural protein; protein tyrosine ... See more keywords
Gypenoside biotransformation into ginsenoside F2 by endophytic Aspergillus niger from Gynostemma pentaphyllum.
Sign Up to like & getrecommendations! Published in 2023 at "Natural product research"
DOI: 10.1080/14786419.2023.2209823
Abstract: Ginsenoside F2 is a protopanaxadiol saponin compound with various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Ginsenoside F2 can be found in ginseng, but in low quantities. Therefore, ginsenoside F2 production predominantly relies on… read more here.
Keywords: gypenoside biotransformation; ginsenoside; biotransformation; aspergillus niger ... See more keywords
Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.885039
Abstract: Recent studies have revealed the pivotal role of gut microbiota in the progress of liver diseases including non-alcoholic steatohepatitis (NASH). Many natural herbs, such as Gynostemma pentaphyllum (GP), have been extensively applied in the prevention… read more here.
Keywords: alcoholic steatohepatitis; non alcoholic; microbiota; gut microbiota ... See more keywords
Effect of Polysaccharide Extracted From Gynostemma Pentaphyllum on the Body Weight and Gut Microbiota of Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.916425
Abstract: Researchers have investigated the role of polysaccharides in disease treatment via gut microbiota regulation but ignore their function in disease prevention and physique enhancement. In this work, a Gynostemma pentaphyllum polysaccharide (GPP) was tested by… read more here.
Keywords: body weight; gynostemma pentaphyllum; microbiota; gut microbiota ... See more keywords
Gynostemma pentaphyllum for dyslipidemia: A systematic review of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.917521
Abstract: Objective: To evaluate the lipid-lowering effect and safety of Gynostemma pentaphyllum (GP) used alone or as adjunctive therapy for dyslipidemia. Methods: Eight databases and three clinical trial registries were searched until January 2022. Randomized controlled… read more here.
Keywords: lowering agents; mmol; gynostemma pentaphyllum; lipid lowering ... See more keywords