The HD-[HD-GYP] Phosphodiesterases; Activities and Evolutionary Diversification within the HD-GYP family.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00257
Abstract: Cyclic dinucleotides are signaling molecules that modulate many processes, including immune response and virulence factor production. Their cellular levels in bacteria are fine-tuned by metal-dependent phosphodiesterases, namely the EAL and HD-GYP proteins, with HD-GYPs belonging… read more here.
Keywords: gyp; phosphodiesterases activities; diversification; activities evolutionary ... See more keywords
Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1070948
Abstract: Gypenosides (GYP) exerted anticancer activity against various cancers. However, the mechanism of GYP against lung cancer (LC) in vivo remains unclear. This study aims to reveal the potential mechanism of GYP against LC and enhancing… read more here.
Keywords: analysis; effects cisplatin; network analysis; pharmacological effects ... See more keywords
Gypenoside L and Gypenoside LI Inhibit Proliferation in Renal Cell Carcinoma via Regulation of the MAPK and Arachidonic Acid Metabolism Pathways
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DOI: 10.3389/fphar.2022.820639
Abstract: Renal cell carcinoma (RCC) has the highest mortality rate of all urological malignancies. Clear cell renal cell carcinoma (ccRCC) accounts for approximately 80% of all RCC cases and is often accompanied by the accumulation of… read more here.
Keywords: cell carcinoma; gyp gyp; renal cell; arachidonic acid ... See more keywords
S-Fertilizer (Elemental Sulfur) Improves the Phytoextraction of Cadmium through Solanum nigrum L.
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DOI: 10.3390/ijerph19031655
Abstract: Soil contamination with toxic heavy metals [such as cadmium (Cd)] is becoming a serious global problem due to the rapid development of the social economy. This study was carried out to assess the beneficial role… read more here.
Keywords: physiology; gyp; elemental sulfur; solanum nigrum ... See more keywords
Gypensapogenin I Ameliorates Isoproterenol (ISO)-Induced Myocardial Damage through Regulating the TLR4/NF-κB/NLRP3 Pathway
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DOI: 10.3390/molecules27165298
Abstract: Myocardial fibrosis (MF) is a common pathological feature of many heart diseases and seriously threatens the normal activity of the heart. Jiaogulan (Gynostemma pentaphyllum) tea is a functional food that is commercially available worldwide. Gypensapogenin… read more here.
Keywords: isoproterenol iso; gypensapogenin ameliorates; ameliorates isoproterenol; tlr4 nlrp3 ... See more keywords