Pharmacophore modeling and molecular dynamics approach to identify putative DNA Gyrase B inhibitors for resistant tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27579
Abstract: One of the major mechanisms followed by the therapeutic agents to target the causative organism of TB, mycobacterium tuberculosis (Mtb), involves disruption of the replication cycle of the pathogen DNA. The process involves two steps… read more here.
Keywords: gyrb domain; pharmacophore; domain; dna gyrase ... See more keywords
In silico designing of domain B selective gyrase inhibitors for effective treatment of resistant tuberculosis.
Sign Up to like & getrecommendations! Published in 2018 at "Tuberculosis"
DOI: 10.1016/j.tube.2018.08.005
Abstract: One of the major mechanisms followed by the therapeutic agents to target the causative organism of TB, Mycobacterium tuberculosis, involves disruption of its DNA replication cycle. The process of replication involves two steps, i.e., breakage… read more here.
Keywords: selective gyrase; gyrase inhibitors; gyrb domain; tuberculosis ... See more keywords