H2S donor GYY4137 mitigates sFlt-1-induced hypertension and vascular dysfunction in pregnant rats
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DOI: 10.1093/biolre/ioae103
Abstract: Abstract Gestational hypertension, often associated with elevated soluble Fms-related receptor tyrosine kinase 1 (sFlt-1), poses significant risks to both maternal and fetal health. Hydrogen sulfide (H2S), a gasotransmitter, has demonstrated blood pressure-lowering effects in hypertensive… read more here.
Keywords: pregnant rats; h2s; gyy4137; sflt induced ... See more keywords
The H2S-Releasing Naproxen Derivative ATB-346 and the Slow-Release H2S Donor GYY4137 Reduce Intestinal Inflammation and Restore Transit in Postoperative Ileus
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DOI: 10.3389/fphar.2019.00116
Abstract: Objective: Intestinal inflammation triggers postoperative ileus (POI), commonly seen after abdominal surgery and characterized by impaired gastrointestinal transit; when prolonged, this leads to increased morbidity. Hydrogen sulfide (H2S) is recognized as an important mediator of… read more here.
Keywords: transit; inflammation; activity; gyy4137 ... See more keywords