Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
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DOI: 10.1126/science.aaz7548
Abstract: Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes… read more here.
Keywords: gsdmb; pyroptosis; cytotoxic; expression ... See more keywords
Hemizygous Granzyme A Mice Expressing the hSOD1G93A Transgene Show Slightly Extended Lifespan
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113554
Abstract: Granzyme A (gzmA), a serine protease involved in the modulation of the inflammatory immune response, is found at an elevated level in the serum from ALS patients. However, the influence of gzmA on the progression… read more here.
Keywords: mice expressing; hsod1g93a transgene; gzma; mice ... See more keywords