Granzyme B mediates impaired healing of pressure injuries in aged skin
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Aging and Mechanisms of Disease"
DOI: 10.1038/s41514-021-00059-6
Abstract: Pressure injuries (PIs), also known as bedsores or pressure ulcers, are a major cause of death and morbidity in the elderly. The serine protease, Granzyme B (GzmB), contributes to skin aging and impaired wound healing.… read more here.
Keywords: granzyme mediates; pressure injuries; impaired healing; gzmb ... See more keywords
Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD
Sign Up to like & getrecommendations! Published in 2024 at "COPD: Journal of Chronic Obstructive Pulmonary Disease"
DOI: 10.1080/15412555.2023.2299104
Abstract: Abstract Chronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small proportion of smokers have disease severe enough to develop COPD. COPD is not always progressive. The question then arises as to… read more here.
Keywords: molecule control; copd; treg cells; effector molecule ... See more keywords
Dual roles of granzyme B
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13086
Abstract: Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour cells and bacteria/virusâinfected cells. However, comprehensive studies conducted on GZMB have gradually revealed the negative extracellular functions of GZMB;… read more here.
Keywords: roles granzyme; gzmb; dual roles; immunology ... See more keywords
Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00509-22
Abstract: Our findings highlight the relative importance of SARS-CoV-2-specific GzmB-producing T cell responses in SARS-CoV-2 control and shared CD4 and CD8 immunodominant epitopes in seasonal coronaviruses or SARS-CoV-1, and they indicate robust persistence of T cell… read more here.
Keywords: cell; gzmb; year; cov specific ... See more keywords
Cytotoxic B Cells in Relapsing-Remitting Multiple Sclerosis Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.750660
Abstract: Background Emerging evidence of antibody-independent functions, as well as the clinical efficacy of anti-CD20 depleting therapies, helped to reassess the contribution of B cells during multiple sclerosis (MS) pathogenesis. Objective To investigate whether CD19+ B… read more here.
Keywords: gzmb; relapsing remitting; cd8 lymphocytes; rrms patients ... See more keywords
Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1648623
Abstract: Introduction Chronic kidney disease (CKD) is a global public health concern characterized by progressive renal function decline and fibrosis, ultimately leading to end-stage renal disease (ESRD). Renal tubular injury and renal interstitial fibrosis are key… read more here.
Keywords: fibrosis; renal fibrosis; renal function; injury ... See more keywords
Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061436
Abstract: Simple Summary Granzyme B (GzmB) is a potent cytotoxic molecule that is used by cytotoxic T lymphocytes and natural killer cells to kill targeted infected or cancerous cells. Since its discovery, there has been growing… read more here.
Keywords: gzmb; cytotoxic; canonical non; cell death ... See more keywords