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   Articles with "gzmk" as a keyword



Exploring GZMK as a prognostic marker and predictor of immunotherapy response in breast cancer: unveiling novel insights into treatment outcomes

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recommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-024-05791-6

Abstract: Granzyme K (GZMK) is a crucial mediator released by immune cells to eliminate tumor cells, playing significant roles in inflammation and tumorigenesis. Despite its importance, the specific role of GZMK in breast cancer and its… read more here.

Keywords: cancer; breast cancer; cell; expression ... See more keywords

Granzyme K - A novel marker to identify the presence and rupture of abdominal aortic aneurysm.

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recommendations! Published in 2021 at "International journal of cardiology"

DOI: 10.1016/j.ijcard.2021.06.014

Abstract: BACKGROUND Immune inflammatory dysfunction is a hallmark of abdominal aortic aneurysm (AAA). Granzyme K (GZMK) is involved in the regulation of inflammation. However, the correlation between GZMK expression and AAA risk remains unknown. METHODS This… read more here.

Keywords: serum gzmk; gzmk expression; gzmk; rupture ... See more keywords

GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases

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recommendations! Published in 2025 at "Nature"

DOI: 10.1038/s41586-024-08395-9

Abstract: Inflammatory diseases are often chronic and recurrent, and current treatments do not typically remove underlying disease drivers1. T cells participate in a wide range of inflammatory diseases such as psoriasis2, Crohn’s disease3, oesophagitis4 and multiple… read more here.

Keywords: disease; expressing cd8; pathology; gzmk expressing ... See more keywords

P1291 Transcriptional heterogeneity of granzyme K CD8 T Cells in Crohn’s Disease: Implications for tissue inflammation

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recommendations! Published in 2025 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjae190.1465

Abstract: Crohn’s disease (CD) pathogenesis involves complex interactions between immune cells and intestinal tissues. We investigated the heterogeneity of CD8 effector T cells (Teff) and their role in CD inflammation at the single-cell level. T cells… read more here.

Keywords: teff; cd8; teff cells; gzmk ... See more keywords

Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0270584

Abstract: Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine proteases produced by cells of the immune system. Previous studies have indicated that GzmK activates protease-activated receptor 1 (PAR1) enhancing activation… read more here.

Keywords: protease activated; granzyme; gzmk; receptor ... See more keywords