Cholangiocyte‐derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans
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DOI: 10.1002/hep.29838
Abstract: Cholestatic liver injury is an important clinical problem with limited understanding of disease pathologies. Exosomes are small extracellular vesicles released by a variety of cells, including cholangiocytes. Exosome‐mediated cell‐cell communication can modulate various cellular functions… read more here.
Keywords: cholestatic liver; hepatology; cholangiocyte derived; liver injury ... See more keywords
Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis
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DOI: 10.1002/hep.30662
Abstract: Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte‐derived exosomal long noncoding RNA‐H19 (lncRNA‐H19) plays a critical role in… read more here.
Keywords: liver fibrosis; liver; cholangiocyte derived; activation ... See more keywords
H19 Promotes HCC Bone Metastasis Through Reducing OPG Expression in a PPP1CA/p38MAPK-Dependent Manner and Sponging miR-200b-3p.
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31673
Abstract: Bone is the second most frequent site of metastasis for hepatocellular carcinoma (HCC), which leads to an extremely poor prognosis. HCC bone metastasis is typically osteolytic, involving the activation of osteoclasts. Long non-coding RNA H19… read more here.
Keywords: metastasis; bone; bone metastasis; hcc bone ... See more keywords
Long noncoding RNA H19 promotes chemotherapy resistance in choriocarcinoma cells
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DOI: 10.1002/jcb.28775
Abstract: Choriocarcinoma (CC) is a trophoblast tumor prone to early distant organ metastases. At present, the main treatment for CC is chemotherapy, but chemotherapy resistance readily occurs and leads to treatment failure. H19 is a long… read more here.
Keywords: jeg mtx; resistance; jeg cells; jeg ... See more keywords
H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17
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DOI: 10.1002/jcp.26530
Abstract: LncRNAs can exhibit crucial roles in the development of multiple cancers, including non‐small cell lung cancer (NSCLC). Currently, we investigated the role of lncRNA H19 in NSCLC. In our study, it was found that H19… read more here.
Keywords: nsclc; mir; lung cancer; development ... See more keywords
H19 regulates the proliferation of bovine male germline stem cells via IGF‐1 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26920
Abstract: Self‐renewal and differentiation of male germline stem cells (mGSCs) provide the basic function for continual spermatogenesis. Studies of in vitro culture of germline stem cells are important and meaningful for basic biological research and practical… read more here.
Keywords: igf signaling; germline stem; signaling pathway; igf ... See more keywords
Involvement of H19/miR‐326 axis in hepatocellular carcinoma development through modulating TWIST1
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DOI: 10.1002/jcp.27319
Abstract: Overexpression of long noncoding RNA (lncRNA) H19 has been observed in various cancers, which indicates that H19 exert important roles in the progression of carcinogenesis. MiR‐326 has been reported to play tumor suppressive roles in… read more here.
Keywords: hcc; mir 326; twist1; h19 mir ... See more keywords
The Fibroblast-Like Synoviocyte Derived Exosomal Long Non-coding RNA H19 Alleviates Osteoarthritis Progression Through the miR-106b-5p/TIMP2 Axis
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DOI: 10.1007/s10753-020-01227-8
Abstract: Osteoarthritis (OA) is a common degenerative joint disease that affects people worldwide. The interaction between fibroblast-like synoviocytes (FLSs) and chondrocytes may play a vital role in OA disease pathology. However, the underlying mechanisms by which… read more here.
Keywords: fibroblast like; timp2 axis; 106b timp2; mir 106b ... See more keywords
Long noncoding RNA H19 prevents neurogenesis in ischemic stroke through p53/Notch1 pathway
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DOI: 10.1016/j.brainresbull.2019.05.009
Abstract: BACKGROUND AND PURPOSE Long non-coding RNA H19 (H19) is one of the earliest discovered long non-coding RNAs. H19 induced the onset of ischemic stroke through regulating neuronal autophagy and microglial polarization. And we aimed to… read more here.
Keywords: ischemic stroke; rna h19; p53; h19 ... See more keywords
LncRNA H19 interacts with S-adenosylhomocysteine hydrolase to regulate LINE-1 Methylation in human lung-derived cells exposed to Benzo[a]pyrene.
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DOI: 10.1016/j.chemosphere.2018.05.048
Abstract: Benzo [a]pyrene (BaP) have been demonstrated to induce lung cancer risk in humans and many different animal models, with aberrant gene methylation as one of the epigenetic errors; however, the molecular mechanisms remain unclear. Here,… read more here.
Keywords: methylation; benzo pyrene; bap; h19 ... See more keywords
Silencing long non-coding RNA H19 combined with paclitaxel inhibits nasopharyngeal carcinoma progression.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2020.110249
Abstract: PURPOSE This study aimed to study the effect of long non-coding RNA (lncRNA) H19 on proliferation, apoptosis and chemosensitivity of nasopharyngeal carcinoma (NPC) cells. METHODS NP69 and HNE3, C666-1, SUNE1, 6-10B and 5-8F cell lines… read more here.
Keywords: h19 combined; combined paclitaxel; lncrna h19; long non ... See more keywords