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Published in 2020 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-020-09828-6
Abstract: Non-small cell lung cancer (NSCLC) constitutes nearly 85% of all cases of lung cancer. Drug resistance, dose-limiting toxicity, and metastasis in NSCLC eventually reduce the efficacy of chemotherapeutics. In this study, we have shown that…
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Keywords:
fraction;
lung cancer;
cancer;
h1975 cells ... See more keywords
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Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.08.1589
Abstract: selected variants of the H1650 and H1975 cell lines for resistance to osimertinib to create models in which mechanisms of resistance can be characterized and tested for potential methods to overcome that resistance. Method: Cells…
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Keywords:
cell lines;
resistance;
osimertinib;
resistant cell ... See more keywords
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Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02314-9
Abstract: Osimertinib (OMB), a third-generation EGFR inhibitor, specifically and irreversibly inhibits EGFRT790M mutant form. Nevertheless, its clinical use is limited due to poor solubility, low absorption, and oral bioavailability. To overcome the low therapeutic capabilities of…
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Keywords:
omb chs;
omb;
mutant egfr;
h1975 ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25122914
Abstract: Rociletinib (CO-1686), a 2,4-diaminopyrimidine derivative, is a highly potent tyrosine kinase inhibitor (TKI) that acts on epidermal growth factor receptor (EGFR) with L858R/T790M mutations. We supposed radioiodinated CO-1686 would function as a useful tool for…
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Keywords:
egfr l858r;
l858r;
h1975;
l858r t790m ... See more keywords
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Published in 2021 at "Neoplasma"
DOI: 10.4149/neo_2021_200506n489
Abstract: Osimertinib (OSI) resistance commonly occurs during the treatment of non-small-cell lung cancer (NSCLC). This study aims to investigate whether the thermal effects of radiofrequency ablation (RFA) can increase the sensitivity of OSI-resistant NSCLC to OSI…
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Keywords:
treatment;
h1975;
h1975 osir;
cell ... See more keywords