Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22394
Abstract: Triptolide (TP), a major active ingredient of Tripterygium wilfordii, exerts potent immunosuppressive effects in the treatment of rheumatoid arthritis but is not widely used in clinical practice due to its multiorgan toxicity, particularly hepatotoxicity, nephrotoxicity,… read more here.
Keywords: triptolide adrenal; adrenal steroidogenesis; h295r; h295r cells ... See more keywords
Comparative analysis of endocrine disrupting effects of major phthalates in employed two cell lines (MVLN and H295R) and embryonic zebrafish assay.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental research"
DOI: 10.1016/j.envres.2019.02.033
Abstract: Endocrine disruption potentials of phthalates have been widely recognized, but relatively little is known about relative potency of major phthalates. In the present study, six phthalates were chosen, i.e., dimethyl phthalate (DMP), diethyl phthalate (DEP),… read more here.
Keywords: endocrine disruption; phthalate; h295r; exposure ... See more keywords
Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.02.010
Abstract: The validated OECD test guideline 456 based on human adrenal H295R cells promotes measurement of testosterone and estradiol production as read-out to identify potential endocrine disrupting chemicals. This study aimed to establish optimal conditions for… read more here.
Keywords: steroid profiling; octyl methoxycinnamate; production; h295r ... See more keywords