The N-terminal tails of histones H2A and H2B adopt two distinct conformations in the nucleosome with contact and reduced contact to DNA.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167110
Abstract: The nucleosome comprises two histone dimers of H2A-H2B and one histone tetramer of (H3-H4)2, wrapped around by ∼145bp of DNA. Detailed core structures of nucleosomes have been established by X-ray and cryo-EM, however, histone tails… read more here.
Keywords: adopt two; h2a tail; dna; h2a h2b ... See more keywords
Rapid divergence of histones in Hydrozoa (Cnidaria) and evolution of a novel histone involved in DNA damage response in hydra.
Sign Up to like & getrecommendations! Published in 2017 at "Zoology"
DOI: 10.1016/j.zool.2017.06.005
Abstract: Histones are fundamental components of chromatin in all eukaryotes. Hydra, an emerging model system belonging to the basal metazoan phylum Cnidaria, provides an ideal platform to understand the evolution of core histone components at the… read more here.
Keywords: evolution; rapid divergence; h2a h2b; hydra ... See more keywords
Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01033
Abstract: Nucleosome assembly proteins (Naps) influence chromatin dynamics by directly binding to histones. Here we provide a comprehensive structural and biochemical analysis of a Nap protein from Caenorhabditis elegans (CeNap1). CeNap1 naturally lacks the acidic N-terminal… read more here.
Keywords: histone binding; uncovers role; h2a h2b; caenorhabditis elegans ... See more keywords
OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19586-z
Abstract: While the yeast Chz1 acts as a specific histone-chaperone for H2A.Z, functions of CHZ-domain proteins in multicellular eukaryotes remain obscure. Here, we report on the functional characterization of OsChz1, a sole CHZ-domain protein identified in… read more here.
Keywords: h2a h2b; chaperone; rice oschz1; histone chaperone ... See more keywords
Antibodies to H2a and H2b histones from the sera of HIV-infected patients catalyze site-specific degradation of these histones.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00042a
Abstract: Histones and their post-translational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecules when they are released into the extracellular space. Administration of histones to animals… read more here.
Keywords: cleavage; h2a h2b; infected patients; cluster ... See more keywords
Histone chaperone Nap1 dismantles an H2A/H2B dimer from a partially unwrapped nucleosome.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad396
Abstract: DNA translocases, such as RNA polymerases, inevitably collide with nucleosomes on eukaryotic chromatin. Upon these collisions, histone chaperones are suggested to facilitate nucleosome disassembly and re-assembly. In this study, by performing in vitro transcription assays… read more here.
Keywords: histone chaperones; histone; h2b dimer; h2a h2b ... See more keywords
Doxorubicin induces large-scale and differential H2A and H2B redistribution in live cells
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231223
Abstract: We observed prominent effects of doxorubicin (Dox), an anthracycline widely used in anti-cancer therapy, on the aggregation and intracellular distribution of both partners of the H2A-H2B dimer, with marked differences between the two histones. Histone… read more here.
Keywords: large scale; doxorubicin induces; h2a h2b; induces large ... See more keywords
FACT caught in the act of manipulating the nucleosome.
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.2210/pdb6upl/pdb
Abstract: The organization of genomic DNA into nucleosomes profoundly affects all DNA-related processes in eukaryotes. The histone chaperone known as 'facilitates chromatin transcription' (FACT1) (consisting of subunits SPT16 and SSRP1) promotes both disassembly and reassembly of… read more here.
Keywords: h2a h2b; dna; caught act; fact caught ... See more keywords