BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation
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DOI: 10.1016/j.molcel.2021.06.020
Abstract: Summary BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for maintaining transcriptional repression. However,… read more here.
Keywords: h2ak119ub1; bap1; repression; bap1 enhances ... See more keywords