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   Articles with "h2ax 53bp1" as a keyword



Effect of boron compounds on the biological effectiveness of proton therapy.

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recommendations! Published in 2022 at "Medical physics"

DOI: 10.1002/mp.15824

Abstract: PURPOSE We assessed whether adding sodium borocaptate (BSH) or 4-borono-L-phenylalanine (BPA) to cells irradiated with proton beams influenced the biological effectiveness of those beams against prostate cancer cells to investigate if the alpha particles generated… read more here.

Keywords: du145 cells; biological effectiveness; effectiveness proton; h2ax 53bp1 ... See more keywords

Assessment of Individual Radiosensitivity in Breast Cancer Patients Using a Combination of Biomolecular Markers

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recommendations! Published in 2023 at "Biomedicines"

DOI: 10.3390/biomedicines11041122

Abstract: About 5% of patients undergoing radiotherapy (RT) develop RT-related side effects. To assess individual radiosensitivity, we collected peripheral blood from breast cancer patients before, during and after the RT, and γH2AX/53BP1 foci, apoptosis, chromosomal aberrations… read more here.

Keywords: 53bp1 foci; cancer patients; breast cancer; h2ax 53bp1 ... See more keywords

Assessment of γ-H2AX and 53BP1 Foci in Peripheral Blood Lymphocytes to Predict Subclinical Hematotoxicity and Response in Somatostatin Receptor-Targeted Radionuclide Therapy for Advanced Gastroenteropancreatic Neuroendocrine Tumors

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recommendations! Published in 2021 at "Cancers"

DOI: 10.3390/cancers13071516

Abstract: Simple Summary Assessment of the radiation-induced alterations in peripheral blood lymphocytes is a validated strategy for biological dosimetry and assessment of individual radiosensitivity. However, its clinical significance as a liquid biopsy for predicting hematotoxicity and… read more here.

Keywords: h2ax 53bp1; response; hematotoxicity; peripheral blood ... See more keywords

Characterization of Aberrations in DNA Damage Repair Pathways in Gastrointestinal Stromal Tumors: The Clinicopathologic Relevance of γH2AX and 53BP1 in Correlation with Heterozygous Deletions of CHEK2, BRCA2, and RB1

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14071787

Abstract: Simple Summary Aberrations of DNA damage repair (DDR) pathways enable the transformation of pre-neoplastic lesions, but their roles are barely understood in gastrointestinal stromal tumors (GISTs). The targeted next-generation sequencing of GISTs has demonstrated heterozygous… read more here.

Keywords: dna damage; h2ax 53bp1; damage repair; gastrointestinal stromal ... See more keywords

Incorporation of Low Concentrations of Gold Nanoparticles: Complex Effects on Radiation Response and Fate of Cancer Cells

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recommendations! Published in 2022 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics14010166

Abstract: (1) Background: In oncology research, a long-standing discussion exists about pros and cons of metal nanoparticle-enhanced radiotherapy and real mechanisms behind the tumor cell response to irradiation (IR) in presence of gold nanoparticles (GNPs). A… read more here.

Keywords: gnp; repair; microscopy; low concentrations ... See more keywords