An improved functional analysis of linker-mediated complex (iFALC) strategy.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.039
Abstract: The functional analysis of linker-mediated complex (FALC) strategy that facilitates functional analysis of a common subunit of multi-subunit protein complexes in cells constitutes three steps; (1) a common subunit is fused to a specific subunit… read more here.
Keywords: common subunit; h2b; strategy; subunit ... See more keywords
Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.08.002
Abstract: Although ADP-ribosylation of histones by PARP-1 has been linked to genotoxic stress responses, its role in physiological processes and gene expression has remained elusive. We found that NAD+-dependent ADP-ribosylation of histone H2B-Glu35 by small nucleolar… read more here.
Keywords: adp ribosylation; histone h2b; functional interplay; h2b ... See more keywords
Generation of LUMCi041-A-2: Equipping a PAX3 reporter iPSC line with doxycycline inducible H2B-mTurquoise2 for live cell imaging.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cell research"
DOI: 10.1016/j.scr.2021.102592
Abstract: An induced pluripotent stem cell (iPSC) line, in which a H2B-fluorescent protein fusion is temporally expressed, is a valuable tool to track cells and study cell divisions and apoptosis. To this end we introduced a… read more here.
Keywords: line; h2b; cell; h2b mturquoise2 ... See more keywords
Nucleosome Core Particles Lacking H2B or H3 Tails Are Altered Structurally and Have Differential Base Excision Repair Fingerprints.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00877
Abstract: A recently discovered post-translational modification of histone proteins is the irreversible proteolytic clipping of the histone N-terminal tail domains. This modification is involved in the regulation of various biological processes, including the DNA damage response.… read more here.
Keywords: excision; h2b; tail; nucleosome core ... See more keywords
The H2BG53D oncohistone directly upregulates ANXA3 transcription and enhances cell migration in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00219-2
Abstract: Dear Editor, Histones are essential proteins in compacting genomic DNA and regulating gene expression. Previous studies on histone H3 oncohistones in pediatric brain cancers and chondroblastoma, documented the transcriptomic reprogramming through the alterations of histone… read more here.
Keywords: transcription; h2b; h2bg53d; g53d ... See more keywords
Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome
Sign Up to like & getrecommendations! Published in 2019 at "Cell Research"
DOI: 10.1038/s41422-019-0146-7
Abstract: Dear Editor, Histone marks deposited by post-translational modifications (PTMs) frequently occur in interrelated combinational patterns to create a complex and precise control on the chromatin structure and function. One of the landmark findings of histone… read more here.
Keywords: surface; supplementary information; h2b; fig ... See more keywords
Association of gastric acid suppression with efficacy of immune checkpoint inhibitors (ICIs) in advanced cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz338.108
Abstract: Abstract Background Recent studies have shown that proton pump inhibitor (PPI) negatively impacts on the clinical benefit from ICIs. Gut microbiome modulated by PPI may contribute to decreased efficacy. It has been also reported that… read more here.
Keywords: ppi; gas; efficacy; h2b ... See more keywords
A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-0393
Abstract: By examination of the cancer genomics database we identified a new set of mutations in core histones that frequently recur in cancer patient samples and are predicted to disrupt nucleosome stability. In support of this… read more here.
Keywords: cancer; histone h2b; histone; h2b ... See more keywords
Doxorubicin induces large-scale and differential H2A and H2B redistribution in live cells
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231223
Abstract: We observed prominent effects of doxorubicin (Dox), an anthracycline widely used in anti-cancer therapy, on the aggregation and intracellular distribution of both partners of the H2A-H2B dimer, with marked differences between the two histones. Histone… read more here.
Keywords: large scale; doxorubicin induces; h2a h2b; induces large ... See more keywords
Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201847563
Abstract: Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly understood. Ferroptosis is a form of non‐apoptotic cell death characterized… read more here.
Keywords: monoubiquitination; regulation ferroptosis; ferroptosis; h2b ... See more keywords
Histone H2B Ubiquitylation Regulates Histone Gene Expression by Suppressing Antisense Transcription in Fission Yeast.
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302499
Abstract: Histone H2B monoubiquitylation (H2Bub1) is tightly linked to RNA polymerase II transcription elongation, and is also directly implicated in DNA replication and repair. Loss of H2Bub1 is associated with defects in cell cycle progression, but how… read more here.
Keywords: h2bub1; transcription; histone h2b; h2b ... See more keywords