Histone H2B Deacylation Selectivity: Exploring Chromatin’s Dark Matter with an Engineered Sortase
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DOI: 10.1021/jacs.1c13555
Abstract: We describe a new method to produce histone H2B by semisynthesis with an engineered sortase transpeptidase. N-Terminal tail site-specifically modified acetylated, lactylated, and β-hydroxybutyrylated histone H2Bs were incorporated into nucleosomes and investigated as substrates of… read more here.
Keywords: chromatin; histone h2b; histone; h2b deacylation ... See more keywords