LAUSR

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.

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1 Published in 2019 at "Molecular cell"

DOI: 10.1016/j.molcel.2019.03.029

Abstract: The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono-ubiquitination of histone H2B on lysine 120 (H2BK120Ub); however, the… read more here.

Keywords: lysine 120; histone h2b; h2b lysine; histone ... See more keywords