Circular RNA circZNF292 regulates H2O2‐induced injury in human lens epithelial HLE‐B3 cells depending on the regulation of the miR‐222‐3p/E2F3 axis
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DOI: 10.1002/cbin.11615
Abstract: Circular RNAs (circRNAs) play important roles in the pathogenesis of age‐related cataract (ARC). CircRNA zinc finger protein 292 (circZNF292, hsa_circ_0004058) is downregulated in ARC lens capsules. Here, we focused on its precise roles in oxidative… read more here.
Keywords: mir 222; h2o2 induced; hle cells; cell ... See more keywords
Thymoquinone protects human retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis
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DOI: 10.1002/jcb.27739
Abstract: Oxidative stress in retinal pigment epithelium (RPE) cells may contribute to the progression of age‐related macular degeneration. Thymoquinone (TQ), an active component derived from Nigella sativa, possesses antioxidative effect. However, the role of TQ in… read more here.
Keywords: apoptosis; induced oxidative; h2o2 induced; oxidative stress ... See more keywords
Synthesis and neuroprotective activity of novel 1,2,4-triazine derivatives with ethyl acetate moiety against H2O2 and Aβ-induced neurotoxicity
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DOI: 10.1007/s00044-017-2003-x
Abstract: A series of 5,6-diaryl-1,2,4-triazine-3-thioacetate derivatives 3a–f, 8a–d and their regioisomer 8e were synthesized. Neuroprotective activity of compounds was assessed against H2O2 and β-amyloid-induced toxicity in PC12 and SH-SY5Y cells respectively. Surprisingly, ethyl 2-(5-(4-chlorophenyl)-6-(4-methoxyphenyl)-3-thioxo-1,2,4-triazin-2(3H)-yl)acetate (8e) was… read more here.
Keywords: activity novel; synthesis neuroprotective; h2o2 induced; neuroprotective activity ... See more keywords
Dalbergioidin (DAL) protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1365-4
Abstract: Reactive oxygen species (ROS) is a pivotal pathogenic factor in the development of osteoporosis. Dalbergioidin (DAL) can be isolated from Uraria crinite, an edible herb used as a natural food for childhood skeletal dysplasia. Recent… read more here.
Keywords: dal; dalbergioidin dal; h2o2; h2o2 induced ... See more keywords
miR-146a down-regulation alleviates H2O2-induced cytotoxicity of PC12 cells by regulating MCL1/JAK/STAT pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-018-9424-2
Abstract: Oxidative stress and miRNAs have been confirmed to play an important role in neurological diseases. The study aimed to explore the underlying effect and mechanisms of miR-146a in H2O2-induced injury of PC12 cells. Here, PC12… read more here.
Keywords: h2o2 induced; mir 146a; pc12 cells; cytotoxicity ... See more keywords
Paeoniflorin Alleviates H2O2-Induced Oxidative Injury Through Down-Regulation of MicroRNA-135a in HT-22 Cells
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DOI: 10.1007/s11064-019-02904-3
Abstract: Paeoniflorin (PF) has been reported to possess neuroprotective influences on cognitive dysfunction illness. In current research, we attempted to probe into the protective influences of PF against H2O2-induced damage and the underlying regulating mechanisms on… read more here.
Keywords: induced oxidative; microrna 135a; mir 135a; h2o2 induced ... See more keywords
Incorporation of Cerium Oxide into Hydroxyapatite Coating Protects Bone Marrow Stromal Cells Against H2O2-Induced Inhibition of Osteogenic Differentiation
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DOI: 10.1007/s12011-017-1066-3
Abstract: Oxidative stress exerts a key influence in osteoporosis in part by inhibiting osteogenic differentiation of bone marrow stromal cells (BMSCs). With their unique antioxidant properties and reported biocompatibility, cerium oxide (CeO2) ceramics exhibit promising potential… read more here.
Keywords: bone; osteogenic differentiation; differentiation; h2o2 induced ... See more keywords
New triterpenoids from Staphylea bumalda flower buds and their neuroprotective activity against H2O2-induced injury in vitro
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DOI: 10.1007/s12272-018-1086-3
Abstract: Four new acylated triterpene glycosides with aliphatic chains (4–7) as well as five known triterpenoids were isolated from the flower buds of Staphylea bumalda with bioassay guidance. Their structures were determined on the basis of… read more here.
Keywords: staphylea bumalda; induced injury; flower buds; new triterpenoids ... See more keywords
JNK1/β-catenin axis regulates H2O2-induced epithelial-to-mesenchymal transition in human lens epithelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.049
Abstract: Epithelial-mesenchymal transition (EMT) is the main cause of fibrotic cataracts. Oxidative stress was recently shown to trigger epithelial-mesenchymal transition in human lens epithelial cells (hLECs). However, the underlying mechanism is not fully understood. Here we… read more here.
Keywords: mesenchymal transition; epithelial mesenchymal; human lens; h2o2 induced ... See more keywords
Cardioprotective effects of constitutively active MEK1 against H2O2-induced apoptosis and autophagy in cardiomyocytes via the ERK1/2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.008
Abstract: Oxidative stress injury is one of the main mechanisms of ischemia-reperfusion (I/R) injury. The extracellular signal-regulated kinase (ERK1/2) pathway plays an important role in cardioprotective during acute myocardial infarction. In this study, we used constitutively… read more here.
Keywords: apoptosis; camek; constitutively active; h2o2 ... See more keywords
Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.
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DOI: 10.1016/j.bcp.2020.113919
Abstract: Achilles tendinopathy has a high re-injury rate and poor prognosis. Development of effective therapy for Achilles tendinopathy is important. Excessive accumulation of ROS and resulting oxidative stress are believed to cause tendinopathy. Overproduction of hydrogen… read more here.
Keywords: achilles tendinopathy; cellular mouse; activator aldh2; h2o2 ... See more keywords