H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.6b06892
Abstract: A self-regulated "smart" insulin administration system would be highly desirable for diabetes management. Here, a glucose-responsive insulin delivery device, which integrates H2O2-responsive polymeric vesicles (PVs) with a transcutaneous microneedle-array patch was prepared to achieve a… read more here.
Keywords: insulin; insulin delivery; insulin release; h2o2 responsive ... See more keywords
A dithiocarbamate-based H2O2-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc05438c
Abstract: Here, we report the rational design of a H2O2-responsive diethyldithiocarbamate (DTC)-based prodrug, which chelated Cu(ii) to form Cu(DTC)2 with a high anticancer activity in a tumor-microenvironment and induced oxidative stress amplification, showing superior antitumor toxicity… read more here.
Keywords: stress amplification; dithiocarbamate based; h2o2 responsive; oxidative stress ... See more keywords
Fabrication of pH/H2O2-responsive polyhedral oligomeric silsesquioxane self-assembled fluorescent vesicles for enhanced in vivo anti-tumor efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Nanomedicine"
DOI: 10.2217/nnm-2021-0302
Abstract: Aim: The rational design of a fluorescence imaging-guided, highly efficient multiresponsive delivery system is important for improving drug delivery efficiency. Materials and methods: Herein, pH/H2O2-responsive polyhedral oligomeric silsesquioxane (POSS) molecule functionalized 4-(phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)amino)benzaldehyde (OTB) copolymer (PEG-POSS-OTB)… read more here.
Keywords: h2o2 responsive; drug delivery; responsive polyhedral; drug ... See more keywords