Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria
Sign Up to like & getrecommendations! Published in 2021 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-021-02065-7
Abstract: We have previously shown that histamine (2-(1H-imidazol-4-yl)ethanamine) exerted concentration-dependent positive inotropic effects (PIE) or positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic (H2R-TG) mice that overexpress the human H2 histamine… read more here.
Keywords: h2r mice; mice human; histamine; h2r ... See more keywords
Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207003120
Abstract: Schizophrenia is a serious mental disorder, and existing antipsychotic drugs show limited efficacy and cause unwanted side effects. The development of glutamatergic drugs for schizophrenia is currently challenging. Most functions of histamine in the brain… read more here.
Keywords: h2r; glutamatergic neurons; pathogenesis schizophrenia; receptor ... See more keywords
Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
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DOI: 10.1242/bio.059191
Abstract: ABSTRACT Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide… read more here.
Keywords: nuclear localization; h2r; histamine; receptor ... See more keywords