Reactive Oxygen Species‐Triggered Hydrogen Sulfide Release and Cancer‐Selective Antiproliferative Effect of Anethole Dithiolethione‐Containing Polymeric Micelles
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DOI: 10.1002/adhm.202201836
Abstract: Hydrogen sulfide (H2S) is a gaseous signaling molecule in the human body and has attracted attention in cancer therapy due to its regulatory roles in cancer cell proliferation and migration. Accumulating evidence suggests that continuous… read more here.
Keywords: anethole dithiolethione; polymeric micelles; release; hydrogen sulfide ... See more keywords
Recyclable Endogenous H2S Activation of Self‐Assembled Nanoprobe with Controllable Biodegradation for Synergistically Enhanced Colon Cancer‐Specific Therapy
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DOI: 10.1002/advs.202203902
Abstract: Excessive production of hydrogen sulfide (H2S) plays a crucial role in the progress of colon cancer. Construction of tumor‐specific H2S‐activated smart nanoplatform with controllable biodegradation is of great significance for precise and sustainable treatment of… read more here.
Keywords: h2s; colon cancer; tumor; biodegradation ... See more keywords
C‐Nitrosothioformamide: A Donor Template for Dual Release of HNO and H2S
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DOI: 10.1002/cbic.202200101
Abstract: C‐Nitrosothioformamide was demonstrated to be a donor template for dual release of HNO and COS triggered by a retro‐Diels‐Alder reaction. COS is an H2S precursor in the presence of carbonic anhydrase. This process produces HNO… read more here.
Keywords: template dual; dual release; hno h2s; h2s ... See more keywords
Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure.
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DOI: 10.1002/cphy.c160023
Abstract: Hydrogen sulfide (H2S) was identified as the third gasotransmitter in 1996 following the discoveries of the biological importance of nitric oxide and carbon monoxide. Although H2S has long been considered a highly toxic gas, the… read more here.
Keywords: protective actions; actions h2s; h2s; heart failure ... See more keywords
An H2S-sensing/CO-releasing Flavonol that Operates via Logic Gates.
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DOI: 10.1002/cplu.201700524
Abstract: Signaling molecules, including H2S and CO, are involved in a complex interplay within cells to maintain cellular homeostasis. In order to investigate the intracellular interplay of different gasotransmitters, new molecular tools are needed that combine… read more here.
Keywords: operates via; releasing flavonol; sensing releasing; h2s sensing ... See more keywords
Hydrogen sulfide attenuates uranium‐induced kidney cells pyroptosis via upregulation of PI3K/AKT/mTOR signaling
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DOI: 10.1002/jbt.23220
Abstract: We have identified that hydrogen sulfide (H2S), a gaseous mediator, plays a crucial role in antioxidative, anti‐inflammatory, and cytoprotective effects on uranium (U)‐triggered rat nephrotoxicity. Pyroptosis is a special mode of inflammation and programmed cell… read more here.
Keywords: pi3k; pi3k akt; pyroptosis; akt mtor ... See more keywords
Altered gene expression of hydrogen sulfide‐producing enzymes in the liver and muscles tissues of hyperthyroid rats
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DOI: 10.1002/jcp.28426
Abstract: Thyroid hormones have a role in the regulation of hydrogen sulfide (H2S) biosynthesis. In this study, we determined the effects of hyperthyroidism on H2S levels in various tissues and messenger RNA (mRNA) expression of cystathionine‐β‐synthase… read more here.
Keywords: liver muscles; hyperthyroidism; hyperthyroid rats; expression ... See more keywords
Progress and perspective on hydrogen sulfide donors and their biomedical applications
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DOI: 10.1002/med.21913
Abstract: Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have shown that H2S is of preventive or therapeutic effects… read more here.
Keywords: hydrogen sulfide; h2s; biomedical applications; h2s donors ... See more keywords
Effect of glucoraphanin and sulforaphane against chemotherapy‐induced neuropathic pain: Kv7 potassium channels modulation by H2S release in vivo
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DOI: 10.1002/ptr.6159
Abstract: The beneficial effects of isothiocyanate‐based compounds, as well as their safety, have been shown in neuropathological disorders, such as neuropathic pain. Aim of the present work was to study the efficacy of the glucosinolate glucoraphanin… read more here.
Keywords: pain; effect; chemotherapy induced; neuropathic pain ... See more keywords
A Common Molecular Switch for H2S to Regulate Multiple Protein Targets.
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DOI: 10.1007/978-981-16-0991-6_1
Abstract: Hydrogen sulfide, a small molecule, produced by endogenous enzymes, such as CTH, CBS, and MPST using L-cysteine as substrates, has been reported to have numerous protective effects. However, the key problem that the target of… read more here.
Keywords: common molecular; protein targets; switch h2s; molecular switch ... See more keywords
Near-infrared fluorescent probe for selective detection of H2S and its application in living animals
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01973-1
Abstract: In this study, a novel near-infrared fluorescent off-on probe for H2S based on seminaphthorhodafluor fluorophore is designed and constructed, which could be used in detection with 121-fold (23-fold) fluorescent (absorbance) enhancement at 630 nm (572 nm), fast… read more here.
Keywords: fluorescent probe; infrared fluorescent; near infrared; fluorescent ... See more keywords