A novel carbazole-based hydrogen-sulfide donor suppresses seizures and upregulates ATP-sensitive potassium channels
Sign Up to like & getrecommendations! Published in 2020 at "Applied Materials Today"
DOI: 10.1016/j.apmt.2020.100559
Abstract: Abstract Epilepsy is characterized by repeated spontaneous seizures and remains untreatable due to its complicate pathogenesis. Low-dose hydrogen sulfide (H2S) has been shown to exert antiepileptic and protective effects in the central nervous system, but… read more here.
Keywords: sensitive potassium; h2s donor; carbazole based; atp sensitive ... See more keywords
Antiproliferative and Proapoptotic Effects of Erucin, A Diet-Derived H2S Donor, on Human Melanoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox12010041
Abstract: Melanoma is the most dangerous form of skin cancer and is characterized by chemotherapy resistance and recurrence despite the new promising therapeutic approaches. In the last years, erucin (ERU), the major isothiocyanate present in Eruca… read more here.
Keywords: h2s donor; melanoma; donor human; melanoma cells ... See more keywords
Protective Effects of H2S Donor Treatment in Experimental Colitis: A Focus on Antioxidants
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DOI: 10.3390/antiox12051025
Abstract: Inflammatory bowel diseases (IBD) are chronic, inflammatory disorders of the gastrointestinal (GI) system, which have become a global disease over the past few decades. It has become increasingly clear that oxidative stress plays a role… read more here.
Keywords: effects h2s; h2s donor; protective effects; colitis ... See more keywords
Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress
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DOI: 10.3390/biom10070995
Abstract: Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids, including homocysteine and exerts neuroprotective effects. An increase of homocysteine during pregnancy impairs fetal growth and development of the offspring due to severe oxidative… read more here.
Keywords: h2s donor; rats maternal; stress; motor ... See more keywords
Vasorelaxant Activity of AP39, a Mitochondria-Targeted H2S Donor, on Mouse Mesenteric Artery Rings In Vitro
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DOI: 10.3390/biom12020280
Abstract: Mitochondria-targeted hydrogen sulfide (H2S) donor compounds, such as compound AP39, supply H2S into the mitochondrial environment and have shown several beneficial in vitro and in vivo effects in cardiovascular conditions such as diabetes and hypertension.… read more here.
Keywords: mouse mesenteric; h2s donor; mesenteric artery; mitochondria targeted ... See more keywords
Anti-Inflammatory Effect of the Natural H2S-Donor Erucin in Vascular Endothelium
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415593
Abstract: Vascular inflammation (VI) represents a pathological condition that progressively affects the integrity and functionality of the vascular wall, thus leading to endothelial dysfunction and the onset of several cardiovascular diseases. Therefore, the research of novel… read more here.
Keywords: inflammatory effect; anti inflammatory; h2s donor;