Progress and perspective on hydrogen sulfide donors and their biomedical applications
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21913
Abstract: Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have shown that H2S is of preventive or therapeutic effects… read more here.
Keywords: hydrogen sulfide; h2s; biomedical applications; h2s donors ... See more keywords
Characterization of H2S releasing properties of various H2S donors utilizing microplate cover-based colorimetric assay.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.03.021
Abstract: In this study, we characterized the potential H2S-releasing properties of seven different H2S donors, including sodium sulfide (Na2S), sodium hydrosulfide (NaHS), diallyl disulfide (DADS), diallyl trisulfide (DATS), sodium thiosulfate (Na2S2O3), morpholin-4-ium 4-methoxyphenyl-morpholino-phosphinodithioate (GYY4137), and Lawesson's… read more here.
Keywords: cover based; h2s; based colorimetric; h2s releasing ... See more keywords
Evaluation of thionolactones as a new type of hydrogen sulfide (H2S) donors for a blood pressure regulation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104650
Abstract: Hydrogen sulfide (H2S) is a gaseous molecule that exhibits various biological effects. For example, H2S has been recognized as a blood pressure-lowering agent. Presented in this report is a new modifiable platform for H2S supply,… read more here.
Keywords: blood pressure; h2s release; sulfide h2s; h2s donors ... See more keywords
Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00279
Abstract: Hydrogen sulfide (H2S) is an important biological mediator, and synthetic H2S donating molecules provide an important class of investigative tools for H2S research. Here, we report esterase-activated H2S donors that function by first releasing carbonyl… read more here.
Keywords: common h2s; esterase triggered; cos h2s; triggered cos ... See more keywords
Toxicities and beneficial protection of H2S donors based on nonsteroidal anti-inflammatory drugs.
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c8md00611c
Abstract: On the basis of our previous study, the H2S donors based on nonsteroidal anti-inflammatory drugs (NSAIDs) were further evaluated with regard to the following aspects: animal blood and urine analyses, liver and kidney toxicities, gastrointestinal… read more here.
Keywords: h2s donors; protection; donors based; anti inflammatory ... See more keywords
Moving Past Quinone-Methides: Recent Advances toward Minimizing Electrophilic Byproducts from COS/H2S Donors.
Sign Up to like & getrecommendations! Published in 2021 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026621666210622130002
Abstract: Hydrogen sulfide (H2S) is an important biomolecule that plays key signaling and protective roles in different physiological processes. With the goals of advancing both the available research tools and the associated therapeutic potential of H2S,… read more here.
Keywords: quinone methides; quinone; past quinone; moving past ... See more keywords
H2S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury via CBS, CSE, and TST Expression
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01134
Abstract: Objective Excess of fructose consumption is related to life-treating conditions that affected more than a third of the global population. Therefore, to identify a newer therapeutic strategy for the impact prevention of high fructose injury… read more here.
Keywords: age related; cse tst; h2s donors; cbs cse ... See more keywords
Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10030429
Abstract: Hydrogen sulfide (H2S) is an endogenous gasotransmitter recently emerged as an important regulatory mediator of numerous human cell functions in health and in disease. In fact, much evidence has suggested that hydrogen sulfide plays a… read more here.
Keywords: trends h2s; chemistry; donors chemistry; cardiovascular diseases ... See more keywords
Comparative Study of Different H2S Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020344
Abstract: In the last years, research proofs have confirmed that hydrogen sulfide (H2S) plays an important role in various physio-pathological processes, such as oxidation, inflammation, neurophysiology, and cardiovascular protection; in particular, the protective effects of H2S… read more here.
Keywords: study different; comparative study; different h2s; h2s ... See more keywords
Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H2S Donors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213804
Abstract: Glaucoma is a group of eye diseases consisting of optic nerve damage with corresponding loss of field vision and blindness. Hydrogen sulfide (H2S) is a gaseous neurotransmitter implicated in various pathophysiological processes. It is involved… read more here.
Keywords: molecular hybrids; design synthesis; hybrids antiglaucoma; drugs h2s ... See more keywords
Role of hydrogen sulfide donors in cancer development and progression
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.47850
Abstract: In recent years, a vast number of potential cancer therapeutic targets have emerged. However, developing efficient and effective drugs for the targets is of major concern. Hydrogen sulfide (H2S), one of the three known gasotransmitters,… read more here.
Keywords: h2s donors; cancer; hydrogen sulfide; donors cancer ... See more keywords