Pyridine and nitro-phenyl linked 1,3,4-thiadiazoles as MDR-TB inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.073
Abstract: In the present study, a series of substituted 1,3,4-thiadiazole derivatives 4(a-o), 5(a-m) and 6(a-j) were synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectroscopic technique. The synthesized compounds were evaluated for their… read more here.
Keywords: mdr strain; pyridine nitro; strain; h37rv ... See more keywords
Mycobacterium tuberculosis stimulates IL-1β production by macrophages in an ESAT-6 dependent manner with the involvement of serum amyloid A3.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.04.022
Abstract: Despite its critical roles in immune responses against tuberculosis infection and immune pathology, the molecular details of interleukin (IL)-1β production in tuberculosis infection remain elusive. To explore IL-1β production in tuberculosis infection, we infected mouse… read more here.
Keywords: bmdms; h37rv; tuberculosis infection; production ... See more keywords
Baicalein regulates NEDD4L-mediated TLR2 ubiquitination to relieve Mycobacterium tuberculosis-induced pneumonia in mice
Sign Up to like & getrecommendations! Published in 2021 at "Food Science and Technology"
DOI: 10.1590/fst.54321
Abstract: Abstract Baicalein has strong anti-inflammatory activity, but its efficacy and mechanism in pneumonia of mice is still unclear. Herein, RAW264.7 cells were infected with M. tuberculosis H37Rv (MOI 1:10) after pre-incubation with 50 μM baicalein,… read more here.
Keywords: pneumonia mice; baicalein; induced pneumonia; mice ... See more keywords
In Silico Identification of Novel Derivatives of Rifampicin Targeting Ribonuclease VapC2 of M. tuberculosis H37Rv: Rifampicin Derivatives Target VapC2 of Mtb H37Rv
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041652
Abstract: The emergence of multi-drug-resistant Mycobacterium tuberculosis (Mtb) strains has rendered many of the currently available anti-TB drugs ineffective. Hence, there is a pressing need to discover new potential drug targets/candidates. In this study, attempts have… read more here.
Keywords: ribonuclease vapc2; h37rv; mtb h37rv; rif ... See more keywords