Personalized medicine modality based on patient-derived xenografts from a malignant transformed GCTB harboring H3F3A G34W mutation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2021.04.004
Abstract: Background The function of H3F3A G43W mutation, which has been observed in almost all GCTB, remains poorly characterized. Breakthrough in malignant GCTB has been trapped by the lack of clinical available drugs, limited canonical patient… read more here.
Keywords: medicine; malignant gctb; pdx model; h3f3a ... See more keywords
The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4291-z
Abstract: BackgroundGiant Cell Tumour of Bone (GCT) is a locally aggressive primary bone tumour that usually occurs at the epiphyses of the long bones of the appendicular skeleton with a tendency to recurrence. Recurrent somatic H3F3A… read more here.
Keywords: long bones; h3f3a; clival lesions; diagnostic algorithm ... See more keywords
Extraneural Metastases From a High-Grade Glioma (HGG) With an H3F3A G34R Mutation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00373
Abstract: Distant metastatic disease from gliomas is extremely rare. We report the case of a 17-year-old female with an H3F3A G34R mutated infiltrative glioma who developed painful osseous metastases to her pelvis and spine within 3… read more here.
Keywords: extraneural metastases; glioma; h3f3a; h3f3a g34r ... See more keywords