Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.03.011
Abstract: The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is required for normal organismal development and maintenance of gene expression… read more here.
Keywords: molecular mechanisms; prc2 recruitment; h3k27 methylation; h3k27 ... See more keywords
Modification of histone 3 lysine 27 (H3K27) trimethylation in EZH2 and JMJD3 deficient T cells attenuates atherosclerosis through polarization towards anti-inflammatory phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3829
Abstract: The trimethylation status of Histone 3 Lysine 27 (H3K27), which is regulated by the methylating enzyme Enchancer of zeste homolog 2 (EZH2) and the demethylating enzyme Jumonji domain containing 3 (JMJD3), is a critical epigenetic… read more here.
Keywords: trimethylation; ezh2 jmjd3; polarization; mice ... See more keywords
The ACF chromatin-remodeling complex is essential for Polycomb repression
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DOI: 10.7554/elife.77595
Abstract: Establishing and maintaining appropriate gene repression is critical for the health and development of multicellular organisms. Histone H3 lysine 27 (H3K27) methylation is a chromatin modification associated with repressed facultative heterochromatin, but the mechanism of… read more here.
Keywords: remodeling complex; acf chromatin; repression; polycomb repression ... See more keywords