Intestinal Inflammation is Linked to Hypoacetylation of Histone 3 Lysine 27 and can be Reversed by Valproic Acid Treatment in Inflammatory Bowel Disease Patients
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.11.009
Abstract: Benefits from biologic therapy for inflammatory bowel disease (IBD) come at a cost of side effects and antidrug antibodies. This necessitates novel anti-inflammatory therapies. Histone acetylation is an important epigenetic gene expression regulator. Acetylation of… read more here.
Keywords: bowel disease; histone lysine; inflammatory bowel; inflammation ... See more keywords
Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00842-x
Abstract: In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is affected by these… read more here.
Keywords: dynamics modulates; expression; allele specific; chromatin conformation ... See more keywords
Mechanism of Stat1 in the neuronal Ca2+ overload after intracerebral hemorrhage via the H3K27ac/Trpm7 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00083.2022
Abstract: Intracerebral hemorrhage (ICH) is classified as a subtype of stroke and Calcium (Ca2+) overload is a catalyst for ICH. This study explored the mechanisms of Stat1 (signal transducer and activator of transcription 1) in the… read more here.
Keywords: neuronal ca2; trpm7; h3k27ac; ca2 overload ... See more keywords
DNA sequence features in the establishing of H3K27ac
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DOI: 10.12688/f1000research.13441.2
Abstract: The presence of H3K27me3 has been demonstrated to correlate with the CpG content. In this work, we tested whether H3K27ac has similar sequence preferences. We performed a translocation of DNA sequences with various properties into… read more here.
Keywords: dna sequence; sequence; features establishing; sequence features ... See more keywords
Transcriptional and H3K27ac related genome profiles in oral squamous cell carcinoma cells treated with metformin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.63234
Abstract: Objectives: Metformin, a first-line drug that has been used for type 2 diabetes treatment, recently attracts broad attention for its therapeutic effects on diverse human cancers. However, its effect and the underlying mechanisms on oral… read more here.
Keywords: cell; cell carcinoma; squamous cell; oral squamous ... See more keywords