Spinal intramedullary H3K27M mutant glioma with vertebral metastasis: a case report
Sign Up to like & getrecommendations! Published in 2021 at "Child's Nervous System"
DOI: 10.1007/s00381-021-05119-6
Abstract: A new entity of gliomas, named “diffuse midline glioma (DMG), H3K27M mutant (grade IV),” which represents a specific molecular profile, was introduced to the World Health Organization (WHO) classification 2016 of central nervous system tumors.… read more here.
Keywords: glioma; h3k27m; case; spinal intramedullary ... See more keywords
Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04489-0
Abstract: H3K27M mutant diffuse midline gliomas (DMGs) are considered grade IV irrespective of histological features and have dismal prognosis. We evaluated clinico-pathologic, radiological, and molecular characteristics of DMGs across all ages. One twenty-six DMGs were identified… read more here.
Keywords: midline gliomas; h3k27m; diffuse midline; h3k27m mutation ... See more keywords
Significance of H3K27M mutation in 'non midline' high grade gliomas of the cerebral hemispheres.
Sign Up to like & getrecommendations! Published in 2019 at "World neurosurgery"
DOI: 10.1016/j.wneu.2019.08.024
Abstract: INTRODUCTION "Diffuse midline glioma H3K27M-mutant" (a mutation genes encoding H3 histone variants) represents a defined pathologic entity since 2016 WHO CNS classifications and include midline structures, namely thalamus, brainstem and spinal cord. H3K27M mutant glioma… read more here.
Keywords: grade; h3k27m; cerebral hemispheres; non midline ... See more keywords
DIPG-34. SUPER ELONGATION COMPLEX AS A TARGETABLE DEPENDENCY IN H3K27M+ DIFFUSE MIDLINE GLIOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.082
Abstract: Abstract Mutations in the histone 3 gene (H3K27M) are the eponymous driver in diffuse intrinsic pontine gliomas (DIPGs) and other diffuse midline gliomas (DMGs), aggressive pediatric brain tumors for which no curative therapy currently exists.… read more here.
Keywords: diffuse; super elongation; h3k27m; elongation complex ... See more keywords
HGG-16. DISSECTING THE EFFECT OF ATM DELETION ON RADIOSENSITIVITY IN DIFFUSE MIDLINE GLIOMAS WITH H3K27M MUTATION
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab090.082
Abstract: Diffuse midline gliomas (DMGs) are responsible for a large proportion of childhood brain tumor deaths. Currently, radiation therapy is thought to be one of the most effective treatment options, but more than 90% of children… read more here.
Keywords: h3k27m; diffuse midline; dmgs; midline gliomas ... See more keywords
STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac093
Abstract: Abstract Background H3K27M-mutant diffuse midline glioma (DMG) is a lethal brain tumor that usually occurs in children. Despite advances in our understanding of its underlying biology, efficacious therapies are severely lacking. Methods We screened a… read more here.
Keywords: cell; mutant dmg; stat3; h3k27m mutant ... See more keywords
Adult diffuse intrinsic pontine glioma: clinical, radiological, pathological, molecular features, and treatments of 96 patients.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurosurgery"
DOI: 10.3171/2022.2.jns211920
Abstract: OBJECTIVE Unlike its pediatric counterpart, adult diffuse intrinsic pontine glioma (DIPG) remains largely unelucidated. In this study, the authors examined the clinical, radiological, pathological, molecular, and clinical aspects of 96 adult DIPGs. METHODS The National… read more here.
Keywords: clinical radiological; adult diffuse; adult; diffuse intrinsic ... See more keywords
Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma
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DOI: 10.3390/cancers13030520
Abstract: Simple Summary Osteosarcoma, Ewing’s sarcoma, and H3K27M-mutant diffuse midline glioma are rare but aggressive malignancies occurring mainly in children. Due to their rareness and often fatal course, drug development is challenging. Here, we repurposed the… read more here.
Keywords: gd2; h3k27m; ewing sarcoma; h3k27m mutant ... See more keywords