Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aao4750
Abstract: The cellular composition of H3K27M gliomas Diffuse midline gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) are an aggressive type of childhood cancer with few options for treatment. Filbin et al. used a single-cell sequencing approach… read more here.
Keywords: single cell; genetics; oncogenic programs; h3k27m gliomas ... See more keywords
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma
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DOI: 10.1158/2159-8290.cd-21-1491
Abstract: The BAF complex, in particular ATPase subunit SMARCA4/BRG1, is critical for maintaining pediatric H3K27M-glioma cells in an oncogenic progenitor state, and pharmacologic inhibition is a potential therapeutic avenue for these highly aggressive tumors. read more here.
Keywords: h3k27m glioma; pediatric h3k27m; baf complex;