Spinal intramedullary H3K27M mutant glioma with vertebral metastasis: a case report
Sign Up to like & getrecommendations! Published in 2021 at "Child's Nervous System"
DOI: 10.1007/s00381-021-05119-6
Abstract: A new entity of gliomas, named “diffuse midline glioma (DMG), H3K27M mutant (grade IV),” which represents a specific molecular profile, was introduced to the World Health Organization (WHO) classification 2016 of central nervous system tumors.… read more here.
Keywords: glioma; h3k27m; case; spinal intramedullary ... See more keywords
H3K27M-mutant glioma in thoracic spinal cord and conus medullaris with pilocytic astrocytoma morphology: case report and review of the literature.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2021.1988054
Abstract: BACKGROUND The H3K27M-mutant spinal cord gliomas are very aggressive with a dismal prognosis, very few cases have been reported in the thoracic spinal cord and conus medullaris, and it is extremely rare with morphological features… read more here.
Keywords: pilocytic astrocytoma; conus medullaris; cord; h3k27m mutant ... See more keywords
DIPG-03. THERAPEUTIC TARGETING OF TRANSCRIPTIONAL ELONGATION IN DIFFUSE INTRINSIC PONTINE GLIOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.055
Abstract: Abstract Diffuse intrinsic pontine glioma (DIPG) is highly aggressive brain stem tumor and needed to develop novel therapeutic agents for the treatment. The super elongation complex (SEC) is essential for transcription elongation through release of… read more here.
Keywords: diffuse intrinsic; elongation; intrinsic pontine; dipg ... See more keywords
HGG-16. DISSECTING THE EFFECT OF ATM DELETION ON RADIOSENSITIVITY IN DIFFUSE MIDLINE GLIOMAS WITH H3K27M MUTATION
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab090.082
Abstract: Diffuse midline gliomas (DMGs) are responsible for a large proportion of childhood brain tumor deaths. Currently, radiation therapy is thought to be one of the most effective treatment options, but more than 90% of children… read more here.
Keywords: h3k27m; diffuse midline; dmgs; midline gliomas ... See more keywords
STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac093
Abstract: Abstract Background H3K27M-mutant diffuse midline glioma (DMG) is a lethal brain tumor that usually occurs in children. Despite advances in our understanding of its underlying biology, efficacious therapies are severely lacking. Methods We screened a… read more here.
Keywords: cell; mutant dmg; stat3; h3k27m mutant ... See more keywords
Prolonged survival in a patient with a cervical spine H3K27M-mutant diffuse midline glioma
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Case Reports"
DOI: 10.1136/bcr-2019-231424
Abstract: We report a case of prolonged survival in a patient with known cervical intramedullary H3K27M-mutant diffuse midline glioma. A 39-year-old man presented for evaluation with several months of progressive upper extremity pain and weakness. MRI… read more here.
Keywords: survival patient; midline glioma; diffuse midline; prolonged survival ... See more keywords
Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma
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DOI: 10.3390/cancers13030520
Abstract: Simple Summary Osteosarcoma, Ewing’s sarcoma, and H3K27M-mutant diffuse midline glioma are rare but aggressive malignancies occurring mainly in children. Due to their rareness and often fatal course, drug development is challenging. Here, we repurposed the… read more here.
Keywords: gd2; h3k27m; ewing sarcoma; h3k27m mutant ... See more keywords