Capturing the Onset of PRC2-Mediated Repressive Domain Formation.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.05.023
Abstract: Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a system whereby PRC2-mediated repressive domains were collapsed and then reconstructed in an… read more here.
Keywords: domain formation; mediated repressive; h3k27me2; prc2 ... See more keywords
PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-20242-9
Abstract: The formation of zygote is the beginning of mammalian life, and dynamic epigenetic modifications are essential for mammalian normal development. H3K27 di-methylation (H3K27me2) and H3K27 tri-methylation (H3K27me3) are marks of facultative heterochromatin which maintains transcriptional… read more here.
Keywords: prc2 ehmt1; establishment; h3k27me2 h3k27me3; h3k27me3 ... See more keywords
Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.215525
Abstract: ABSTRACT Dysregulation of the homeostatic balance of histone H3 di- and tri-methyl lysine 27 (H3K27me2/3) levels caused by the mis-sense mutation of histone H3 (H3K27M) is reported to be associated with various types of cancers.… read more here.
Keywords: genome stability; fancd2 chromatin; histone; h3k27me2 ... See more keywords