Predictive significance of circulating histones in hepatocellular carcinoma patients treated with sorafenib.
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DOI: 10.2217/epi-2021-0383
Abstract: Background: Predictive biomarkers for advanced hepatocellular carcinoma are lacking. EZH2 drives sorafenib resistance through H3K27me3 and is counteracted by SETD2, which catalyzes H3K36me3. The authors tested the predictive power of circulating H3K27me3 and H3K36me3 in… read more here.
Keywords: carcinoma patients; h3k27me3 h3k36me3; hepatocellular carcinoma; treated sorafenib ... See more keywords