C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0247-3
Abstract: The polycomb repressive complex 2 (PRC2) catalyzes the methylation of histone H3 on lysine 27 (H3K27) to generate trimethyl-H3K27 (H3K27me3) marks, thereby leading to a repressive chromatin state that inhibits gene expression. C10ORF12 was recently… read more here.
Keywords: histone methyltransferase; h3k27me3 levels; methyltransferase activity; h3k27me3 ... See more keywords
EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00889-0
Abstract: Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases and repress the transcription of target genes. Dysregulation of H3K27 trimethylation (H3K27me3) plays an important role in the development and progression… read more here.
Keywords: hepatocellular carcinoma; h3k27me3 levels; ezh1; sorafenib ... See more keywords