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   Articles with "h3k36" as a keyword



Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality

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recommendations! Published in 2021 at "Cell Reports"

DOI: 10.1016/j.celrep.2021.110050

Abstract: Summary Germ cells have evolved unique mechanisms to ensure the transmission of genetically and nongenetically encoded information, whose alteration compromises germ cell immortality. Chromatin factors play fundamental roles in these mechanisms. H3K36 and H3K27 methyltransferases… read more here.

Keywords: germ cell; methylation; h3k36; histone ... See more keywords

Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-57556-5

Abstract: The histone H3K36-specific methyltransferase ASH1L plays a critical role in development and is frequently dysregulated in human diseases, particularly cancer. Here, we report on the biological functions of the C-terminal region of ASH1L encompassing a… read more here.

Keywords: ash1l; histone h3k36; structure function; h3k36 ... See more keywords

H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.adt8765

Abstract: Metazoan nucleosomes harboring H3K79 methylation (H3K79me) deposited by the methyltransferase DOT1L (disruptor of telomeric silencing 1-like) decorate actively transcribed genes. While DOT1L regulates transcription and the pathogenesis of leukemia and neurological disorders, the role of… read more here.

Keywords: h3k36 trimethylation; gene expression; h3k36; h3k79me ... See more keywords

Clinical and histopathologic characterization of SETD2-mutated colorectal cancer.

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recommendations! Published in 2022 at "Human pathology"

DOI: 10.2139/ssrn.4247261

Abstract: With the advent of next-generation sequencing (NGS), identifying and better understanding genetic mutations in cancer pathways has become more feasible. A mutation now commonly reported in NGS panels is the SETD2 gene (H3K36 trimethyltransferase). However,… read more here.

Keywords: pathology; h3k36; mutation; setd2 ... See more keywords