H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adt8765
Abstract: Metazoan nucleosomes harboring H3K79 methylation (H3K79me) deposited by the methyltransferase DOT1L (disruptor of telomeric silencing 1-like) decorate actively transcribed genes. While DOT1L regulates transcription and the pathogenesis of leukemia and neurological disorders, the role of… read more here.
Keywords: h3k36 trimethylation; gene expression; h3k36; h3k79me ... See more keywords