H3K4 trimethylation dynamics impact diverse developmental and environmental responses in plants
Sign Up to like & getrecommendations! Published in 2021 at "Planta"
DOI: 10.1007/s00425-020-03520-0
Abstract: Main conclusion The H3K4me3 histone mark in plants functions in the regulation of gene expression and transcriptional memory, and influences numerous developmental processes and stress responses. Abstract Plants execute developmental programs and respond to changing… read more here.
Keywords: trimethylation; gene expression; h3k4me3; developmental environmental ... See more keywords
Epigenetic changes occur in placentas of spontaneous and recurrent miscarriages.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103466
Abstract: BACKGROUND In contrast to genetic abnormalities which are well known to be responsible for around 50 % of human miscarriages, there is very few data about epigenetic alterations in spontaneous and recurrent miscarriages (SM, RM).… read more here.
Keywords: h3k4me3 h3k9ac; recurrent miscarriages; h3k4me3; placental tissue ... See more keywords
Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.04.009
Abstract: Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is… read more here.
Keywords: memory formation; histone lysine; lysine trimethylation; h3k4me3 ... See more keywords
Stable H3K4me3 is associated with transcription initiation during early embryo development
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz173
Abstract: MOTIVATION During development of the mammalian embryo, histone modification H3K4me3 plays an important role in regulating gene expression and exhibits extensive reprogramming on the parental genomes. In addition to these dramatic epigenetic changes, certain unchanging… read more here.
Keywords: initiation; h3k4me3; embryo; h3k4me3 associated ... See more keywords
KDM5-mediated redistribution of H3K4me3 is required for oocyte-to-embryonic transition in cattle
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac047
Abstract: Abstract Reprogramming of histone modifications is critical to safeguard correct gene expression profile during preimplantation development. Of interest, trimethylation of lysine 4 on histone 3 (H3K4me3) exhibits a unique and dynamic landscape with a potential… read more here.
Keywords: h3k4me3; kdm5 mediated; redistribution h3k4me3; oocyte embryonic ... See more keywords
Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab154
Abstract: Abstract Hydroxamate-based lysine deacetylase inhibitors (KDACis) are approved for clinical use against certain cancers. However, intrinsic and acquired resistance presents a major problem. Treatment of cells with hydroxamates such as trichostatin A (TSA) leads to… read more here.
Keywords: acetylation; sensitivity; h3k4me3; directed acetylation ... See more keywords
Unscheduled epigenetic modifications cause genome instability and sterility through aberrant R-loops following starvation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1155
Abstract: Abstract During starvation, organisms modify both gene expression and metabolism to adjust to the energy stress. We previously reported that Caenorhabditis elegans lacing AMP-activated protein kinase (AMPK) exhibit transgenerational reproductive defects associated with abnormally elevated… read more here.
Keywords: h3k4me3; following starvation; modifications cause; starvation ... See more keywords
A new method to synthesize multiple gRNA libraries and functional mapping of mammalian H3K4me3 regions
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad198
Abstract: Abstract Genetic screening based on the clustered regularly interspaced palindromic repeat (CRISPR) system has been indicated to be a powerful tool for identifying regulatory genes or cis-elements. However, when applying CRISPR screens to pinpoint functional… read more here.
Keywords: h3k4me3; method synthesize; multiple grna; synthesize multiple ... See more keywords
Decoding the function of bivalent chromatin in development and cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.275736.121
Abstract: Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and H3K27me3, histone modifications generally associated with transcriptionally active and repressed chromatin, respectively. Prevalent in embryonic stem cells (ESCs), bivalency is postulated to poise/prime lineage-controlling… read more here.
Keywords: bivalent; bivalency; h3k4me3; bivalent chromatin ... See more keywords
Coordination of zygotic genome activation entry and exit by H3K4me3 and H3K27me3 in porcine early embryos
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.276207.121
Abstract: Histone modifications are critical epigenetic indicators of chromatin state associated with gene expression. Although the reprogramming patterns of H3K4me3 and H3K27me3 have been elucidated in mouse and human preimplantation embryos, the relationship between these marks… read more here.
Keywords: h3k4me3; h3k27me3; zygotic genome; embryos ... See more keywords
H3K4me3 recognition by the COMPASS complex facilitates the restoration of this histone mark following DNA replication
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm6246
Abstract: During DNA replication, parental H3-H4 marked by H3K4me3 are transferred almost equally onto leading and lagging strands of DNA replication forks. Mutations in replicative helicase subunit, Mcm2 (Mcm2-3A), and leading strand DNA polymerase subunit, Dpb3… read more here.
Keywords: h3k4me3; restoration; dna; dna replication ... See more keywords