LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "h3k79 methylation" as a keyword



H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells

Sign Up to like & get
recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.adt8765

Abstract: Metazoan nucleosomes harboring H3K79 methylation (H3K79me) deposited by the methyltransferase DOT1L (disruptor of telomeric silencing 1-like) decorate actively transcribed genes. While DOT1L regulates transcription and the pathogenesis of leukemia and neurological disorders, the role of… read more here.

Keywords: h3k36 trimethylation; gene expression; h3k36; h3k79me ... See more keywords

Tight Regulation of H3K79 Methylation Levels in KMT2A-Rearranged AML

Sign Up to like & get
recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-114784

Abstract: Rationale: KMT2A-rearrangements (KMT2A-r) in acute myeloid leukemia (AML), encompassing both KMT2a-fusions (KMT2A-F) and KMT2A-partial tandem duplications (KMT2A-PTD), represent a subgroup of AML with a particularly poor prognosis. Both KMT2A-F and KMT2A-PTD share a dependency on… read more here.

Keywords: methylation; midh1; h3k79 methylation; kmt2a ... See more keywords

Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML.

Sign Up to like & get
recommendations! Published in 2020 at "Blood advances"

DOI: 10.1182/bloodadvances.2020001922

Abstract: Understanding mechanisms of cooperation between oncogenes is critical for the development of novel therapies and rational combinations. Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2APTD) are known to depend on… read more here.

Keywords: methylation; patterns h3k79; methylation influence; interaction ... See more keywords

Neuronal Dot1l Activity Acts as a Mitochondrial Gene-Repressor Associated with Human Brain Aging via H3K79 Hypermethylation

Sign Up to like & get
recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24021387

Abstract: Methylation of histone 3 at lysine 79 (H3K79) and its catalyst, a disrupter of telomeric silencing (DOT1l), have been coupled to multiple forms of stress, such as bioenergetic and ER challenges. However, studies on H3K79… read more here.

Keywords: brain aging; dot1l; methylation; h3k79 methylation ... See more keywords