Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis
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DOI: 10.1136/ard-2022-223789
Abstract: Objectives In osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by histone methyltransferases and demethylases. Here, we aimed to identify which histone… read more here.
Keywords: methylation; histone; histone demethylases; protects osteoarthritis ... See more keywords