Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.122
Abstract: Tumor-repopulating cells (TRCs) are a tumorigenic sub-population of cancer cells that drives tumorigenesis. We have recently reported that soft fibrin matrices maintain TRC growth by promoting histone 3 lysine 9 (H3K9) demethylation and Sox2 expression… read more here.
Keywords: tumor repopulating; repopulating cells; fibrin matrices; h3k9 methylation ... See more keywords
MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.03.008
Abstract: In C. elegans, alterations to chromatin produce transgenerational effects, such as inherited increase in lifespan and gradual loss of fertility. Inheritance of histone modifications can be induced by double-stranded RNA-derived heritable small RNAs. Here, we show… read more here.
Keywords: small rna; h3k9 methylation; inheritance; rna inheritance ... See more keywords
Fast H3K9 methylation promoted by CXCL12 contributes to nuclear changes and invasiveness of T-acute lymphoblastic leukemia cells
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-021-02168-8
Abstract: T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that comprises the accumulation of malignant T-cells. Despite current therapies, failure to conventional treatments and relapse are frequent in children with T-ALL. It is known that… read more here.
Keywords: h3k9 methylation; methylation; acute lymphoblastic; lymphoblastic leukemia ... See more keywords
Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24532-8
Abstract: Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes:… read more here.
Keywords: heterochromatin organization; methylation; h3k9 methylation; set domain ... See more keywords
Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac716
Abstract: Abstract Post-translational modifications (PTMs) of core histones are important epigenetic determinants that correlate with functional chromatin states. However, despite multiple linker histone H1s PTMs have been identified, little is known about their genomic distribution and… read more here.
Keywords: h3k9 methylation; methylation; heterochromatin organization; linker histone ... See more keywords
Melatonin protects prepuberal testis from deleterious effects of bisphenol A or diethylhexyl phthalate by preserving H3K9 methylation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12497
Abstract: A growing number of couples experience fertility issues with almost half being due to malefactors. The exposure to toxic environmental contaminants, such as endocrine disruptors (EDs), has been shown to negatively affect male fertility. EDs… read more here.
Keywords: spermatogenesis; methylation; diethylhexyl phthalate; h3k9 methylation ... See more keywords
Heterochromatin: did H3K9 methylation evolve to tame transposons?
Sign Up to like & getrecommendations! Published in 2021 at "Genome Biology"
DOI: 10.1186/s13059-021-02550-5
Abstract: * Correspondence: guillaume.filion@ utoronto.ca Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Scarborough, M1C1A4 ON, Canada Chromatin is traditionally studied in the fields of DNA repair and gene regulation, not immunology. Yet,… read more here.
Keywords: chromatin; h3k9 methylation; methylation; non ltr ... See more keywords
Differential phosphorylation of Clr4SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202255928
Abstract: Methylation of histone H3 at lysine 9 (H3K9) is a hallmark of heterochromatin that plays crucial roles in gene silencing, genome stability, and chromosome segregation. In Schizosaccharomyces pombe, Clr4 mediates both di‐ and tri‐methylation of… read more here.
Keywords: h3k9 methylation; methylation; methylation switch; differential phosphorylation ... See more keywords
Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2019.4446
Abstract: The morbidity of temporomandibular joint osteoarthritis (TMJOA) increases with age. Condylar articular cartilage degradation, which causes TMJOA, is known to be involved in articular chondrocyte metabolic imbalances in the temporomandibular joint (TMJ) and in other… read more here.
Keywords: histone h3k9; methylation; temporomandibular joint; h3k9 methylation ... See more keywords
An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53155
Abstract: H3K9 methylation (H3K9me) specifies the establishment and maintenance of transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone modifications is widely assumed to be the primary mechanism that reverses epigenetic silencing. Here, we… read more here.
Keywords: interaction; histone; h3k9 methylation; putative histone ... See more keywords