Genome-wide identification of histone methylation (H3K9me2) and acetylation (H4K12ac) marks in two ecotypes of switchgrass (Panicum virgatum L.)
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-6038-x
Abstract: BackgroundHistone modifications play a significant role in the regulation of transcription and various biological processes, such as development and regeneration. Though a few genomic (including DNA methylation patterns) and transcriptomic studies are currently available in… read more here.
Keywords: genome wide; methylation; switchgrass; h4k12ac ... See more keywords
Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0216463
Abstract: Schizophrenia has been consistently characterized by abnormal patterns of gene down-regulation, increased restrictive chromatin assemblies, and reduced transcriptional activity. Histone methyltransferase (HMT) mRNA and H3K9me2 levels are elevated in postmortem brain and peripheral blood cells… read more here.
Keywords: histone methyltransferase; inhibitor bix; bix 01294; gene ... See more keywords
Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma
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DOI: 10.18632/oncotarget.15528
Abstract: Histone H3 lysine 9 dimethylation (H3K9me2) is mainly regulated by the histone lysine methyltransferase G9a and is associated with the repression of transcription. However, both the role of G9a and the significance of H3K9me2 in… read more here.
Keywords: hcc; histone lysine; lysine methyltransferase; growth ... See more keywords
Writing and Reading Histone H3 Lysine 9 Methylation in Arabidopsis
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DOI: 10.3389/fpls.2020.00452
Abstract: In eukaryotes, histone H3 lysine 9 methylation (H3K9me) mediates the silencing of invasive and repetitive sequences by preventing the expression of aberrant gene products and the activation of transposition. In Arabidopsis, while it is well… read more here.
Keywords: methylation; lysine methylation; histone lysine; arabidopsis ... See more keywords
Differential H3K9me2 heterochromatin levels and concordant mRNA expression in postmortem brain tissue of individuals with schizophrenia, bipolar, and controls
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.1006109
Abstract: The existence of repressive and durable chromatin assemblies along gene promoters or networks, especially in the brain, is of theoretical and therapeutic relevance in a subset of individuals diagnosed with schizophrenia who experience a chronic,… read more here.
Keywords: postmortem brain; brain; brain tissue; mrna expression ... See more keywords
H3K9me2 regulates early transcription factors to promote mesenchymal stem‑cell differentiation into cardiomyocytes.
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DOI: 10.3892/mmr.2021.12255
Abstract: Studies have shown that histone H3 at lysine 9 (H3K9me2) is an important epigenetic modifier of embryonic development, cell reprogramming and cell differentiation, but its specific role in cardiomyocyte formation remains to be elucidated. The present… read more here.
Keywords: transcription; cell; cardiomyocyte formation; transcription factors ... See more keywords
Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Letters"
DOI: 10.3892/ol.2020.11694
Abstract: Di-methylated lysine 9 of histone H3 (H3K9me2), regulated by histone methyltransferases, is involved in the epigenetic regulation of tumor-associated genes. The present study aimed to evaluate whether the H3K9me2 methylation level is associated with the… read more here.
Keywords: prognosis gastric; level; expression; h3k9me2 ehmt2 ... See more keywords