HP1α is highly expressed in glioma cells and facilitates cell proliferation and survival.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.056
Abstract: Epigenetic alteration plays critical roles in gliomagenesis by regulating gene expression through modifications of Histones and DNA. Trimethylation of H3K9, an essential repressed transcription mark, and one of its methyltransferase, SUV39H1, are implicated in glioma… read more here.
Keywords: glioma; cell proliferation; hp1; h3k9me3 ... See more keywords
Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.130
Abstract: Protein-tyrosine kinases transmit signals by phosphorylating their substrates in diverse cellular events. The receptor-type tyrosine kinase ErbB4, a member of the epidermal growth factor receptor subfamily, is activated and proteolytically cleaved upon ligand stimulation, and… read more here.
Keywords: histone h3k9; trimethylation histone; tyrosine; h3k9me3 ... See more keywords
Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1101/2022.09.04.506543
Abstract: H3K9me3-based gene silencing is a conserved strategy for securing cell fate, but the mechanisms controlling lineage-specific installation of this epigenetic mark remain unclear. In Drosophila, H3K9 methylation plays an essential role in securing female germ… read more here.
Keywords: cell; germ; identity; mini ... See more keywords
Spatial Multiplexed Protein Profiling of Cardiac Ischemia-Reperfusion Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Circulation research"
DOI: 10.1161/circresaha.123.322620
Abstract: BACKGROUND Reperfusion therapy is critical to myocardial salvage in the event of a myocardial infarction but is complicated by ischemia-reperfusion injury (IRI). Limited understanding of the spatial organization of cardiac cells, which governs cellular interaction… read more here.
Keywords: reperfusion injury; iri; reperfusion; h3k9me3 ... See more keywords
Exercise Reduces H3K9me3 and Regulates Brain Derived Neurotrophic Factor and GABRA2 in an Age Dependent Manner
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.798297
Abstract: Exercise improves cognition in the aging brain and is a key regulator of neuronal plasticity genes such as BDNF. However, the mechanism by which exercise modifies gene expression continues to be explored. The repressive histone… read more here.
Keywords: bdnf; age; expression; gabra2 ... See more keywords
Genome-wide analysis of epigenetic and transcriptional changes in the pathogenesis of RGSV in rice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1090794
Abstract: Rice grassy stunt virus (RGSV), a typical negative single-stranded RNA virus, invades rice and generates several disease signs, including dwarfing, tillering, and sterility. Previous research has revealed that RGSV-encoded proteins can force the host’s ubiquitin-proteasome… read more here.
Keywords: genome wide; rice; analysis; h3k9me3 ... See more keywords