4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies.
Sign Up to like & getrecommendations! Published in 2017 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520616666160926113109
Abstract: BACKGROUND Cancer is one of the most serious clinical problems worldwide, and considerable efforts have been devoted to discovering therapeutic agents with novel modes of action. Natural and synthetic coumarin derivatives have attracted intense research… read more here.
Keywords: h460 cells; anticancer agents; compound; cell ... See more keywords
COX-2 potentiates cisplatin resistance of non-small cell lung cancer cells by promoting EMT in an AKT signaling pathway-dependent manner.
Sign Up to like & getrecommendations! Published in 2019 at "European Review for Medical and Pharmacological Sciences"
DOI: 10.26355/eurrev_201905_17811
Abstract: OBJECTIVE To elucidate the effect of cyclooxygenase 2 (COX-2) on cisplatin resistance of NSCLC and its molecular mechanisms, with special attention to its pro-EMT (epithelial-mesenchymal transition) properties. MATERIALS AND METHODS COX-2 levels were compared in… read more here.
Keywords: cox; cisplatin resistance; signaling pathway; akt signaling ... See more keywords