Broad histone H4 mono-methylation marks expressed genes involved in translation.
Sign Up to like & getrecommendations! Published in 2023 at "Genome"
DOI: 10.1139/gen-2023-0011
Abstract: H4K20me1 (histone H4 methylated at lysine 20) generally has a broad distribution along genes and has been reported to be associated with expressed and repressed genes. In contrast, H3K4me3 (histone H3 trimethylated at lysine 4)… read more here.
Keywords: histone; broad histone; expressed genes; genes involved ... See more keywords
LukS-PV Induces Apoptosis via the SET8-H4K20me1-PIK3CB Axis in Human Acute Myeloid Leukemia Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.718791
Abstract: Evidence suggests that histone modification disorders are involved in leukemia pathogenesis. We previously reported that LukS-PV, a component of Panton–Valentine leukocidin (PVL), has antileukemia activities that can induce differentiation, increase apoptosis, and inhibit proliferation of… read more here.
Keywords: apoptosis; myeloid leukemia; pik3cb; h4k20me1 ... See more keywords