H3K9me3, H3K36me3, and H4K20me3 Expression Correlates with Patient Outcome in Esophageal Squamous Cell Carcinoma as Epigenetic Markers
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05529-2
Abstract: BackgroundHistone methylation, as an essential pattern of posttranslational modifications, contributes to multiple cancer-related biological processes. Dysregulation of histone methylation is now considered a biomarker for cancer prognosis.AimsThis study investigated and evaluated the potential role of… read more here.
Keywords: prognosis; lysine trimethylation; h4k20me3; expression ... See more keywords
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
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DOI: 10.1038/s41467-021-22665-4
Abstract: DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk.… read more here.
Keywords: methylation; line; h4k20me3; dnmt1 ... See more keywords