Preliminary study of histamine H4 receptor expressed on human CD4+ T cells and its immunomodulatory potency in the IL-17 pathway of psoriasis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.05.011
Abstract: BACKGROUND Previous studies have shown the expression of histamine H4 receptor (H4R) on CD4+ T cells, especially human CD4+ Th2-polarized T cells. OBJECTIVE This study aimed to investigate the role of H4R on these effector… read more here.
Keywords: cd4 cells; h4r; expression; psoriasis ... See more keywords
Behavioural phenotype of histamine H4 receptor knockout mice: Focus on central neuronal functions
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.11.023
Abstract: ABSTRACT The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal… read more here.
Keywords: behavioural phenotype; h4r; h4r deficient; neuronal functions ... See more keywords
Histamine therapeutic efficacy in metastatic melanoma: Role of histamine H4 receptor agonists and opportunity for combination with radiation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15594
Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a… read more here.
Keywords: melanoma; h4r; therapeutic efficacy; histamine ... See more keywords
Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00556
Abstract: Cancer is a leading cause of death in both developed and developing countries. Although advances in cancer research lead to improved anti-neoplastic therapies, they continue to have unfavorable outcomes, including poor response and severe toxicity.… read more here.
Keywords: h4r; pharmacology; pathophysiological role; cancer ... See more keywords
Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031378
Abstract: The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the role of histamine in numerous physiological and pathological conditions, including tumor development and progression. The lymph nodes of patients… read more here.
Keywords: histamine; histamine receptor; cell lymphoma; h4r ... See more keywords